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说明： Selective sirtuin family deacetylase inhibitor
化学名： 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
纯度： ≥98% (HPLC)
生物活性 for Sirtinol
Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC50 values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.
技术数据 for Sirtinol
| 分子量 | 394.47 |
| 公式 | C26H22N2O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 410536-97-9 |
| PubChem ID | 5717148 |
| InChI Key | YUGODMKHHCZZOI-QJOMJCCJSA-N |
| Smiles | O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Sirtinol
参考文献 for Sirtinol
参考文献是支持产品生物活性的出版物。
Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837 PMID: 11483616
Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818
Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364 PMID: 19008647
Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823 PMID: 19075016
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关键词: Sirtinol, Sirtinol supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Class, III, HDACs, (Sirtuins), 3521, Tocris Bioscience
6 篇 Sirtinol 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Sirtinol 的部分引用包括：
Kirby D et al (2012) Activation of the stress proteome as a mechanism for small molecule therapeutics. Hum Mol Genet 21 4237-52 PMID: 22752410
María J et al (2011) The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes 60 1177-85 PMID: 21386086
Balaiya et al (2012) Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis 18 114 PMID: 22275802
Stoney et al (2016) Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia 64 425 PMID: 26527258
M T et al (2014) Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis 5 e1296 PMID: 24946089
Paffett et al (2011) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol 56 64 PMID: 22146233
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该领域的文献
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