Sirtinol

Cat. No. 3521 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective sirtuin family deacetylase inhibitor

化学名： 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide

纯度： ≥98% (HPLC)

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Sirtinol

Sirtinol is a cell-permeable, selective sirtuin deacetylase inhibitor (IC₅₀ values are 38, 68 and 131 μM at SIRT2, Sir2p and SIRT1 respectively) that has no effect on HDAC1 activity. Significantly decreases growth and viability of PCa and HEK293T cells in vitro.

技术数据 for Sirtinol

分子量	394.47
公式	C₂₆H₂₂N₂O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	410536-97-9
PubChem ID	5717148
InChI Key	YUGODMKHHCZZOI-QJOMJCCJSA-N
Smiles	O=C(NC(C)C3=CC=CC=C3)C1=CC=CC=C1/N=C/C2=C(C=CC=C4)C4=CC=C2O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Sirtinol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	39.45	100

制备储备液 for Sirtinol

以下数据基于产品分子量 394.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.54 mL	12.68 mL	25.35 mL
5 mM	0.51 mL	2.54 mL	5.07 mL
10 mM	0.25 mL	1.27 mL	2.54 mL
50 mM	0.05 mL	0.25 mL	0.51 mL

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产品说明书 for Sirtinol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Sirtinol

参考文献是支持产品生物活性的出版物。

Grozinger et al (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J.Biol.Chem. 276 38837 PMID: 11483616

Mai et al (2005) Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (sirtuin) inhibitors. J.Med.Chem. 48 7789 PMID: 16302818

Kahyo et al (2008) A novel chalcone polyphenol inhibits the deacetylase activity of SIRT1 and cell growth in HEK293T cells. J.Pharmacol.Sci. 108 364 PMID: 19008647

Jung-Hynes et al (2009) Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J.Biol.Chem. 284 3823 PMID: 19075016

If you know of a relevant reference for Sirtinol, please let us know.

按标靶查看相关产品

关键词: Sirtinol, Sirtinol supplier, Selective, sirtuin, family, deacetylases, inhibitors, inhibits, Sirtuin, Sir2-like, Family, Class, III, HDACs, (Sirtuins), 3521, Tocris Bioscience

6 篇 Sirtinol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Sirtinol 的部分引用包括：

Balaiya et al (2012) Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α. Mol Vis 18 114 PMID: 22275802

Stoney et al (2016) Thyroid hormone activation of retinoic acid synthesis in hypothalamic tanycytes. Glia 64 425 PMID: 26527258

M T et al (2014) Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways. Cell Death Dis 5 e1296 PMID: 24946089

Paffett et al (2011) Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle. Vascul Pharmacol 56 64 PMID: 22146233

Kirby D et al (2012) Activation of the stress proteome as a mechanism for small molecule therapeutics. Hum Mol Genet 21 4237-52 PMID: 22752410

María J et al (2011) The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin. Diabetes 60 1177-85 PMID: 21386086

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