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SKF 86002 dihydrochloride

Cat. No. 2008 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2008 has been discontinued.

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说明： p38 MAPK inhibitor; anti-inflammatory agent
化学名： 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for SKF 86002 dihydrochloride

Inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). Also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 values are 10 and 100 μM respectively). Anti-inflammatory following oral administration in vivo.

技术数据 for SKF 86002 dihydrochloride

分子量 370.27
公式 C16H12FN3S.2HCl
储存 Desiccate at +4°C
纯度 ≥98% (HPLC)
CAS Number 116339-68-5
PubChem ID 10339107
InChI Key GQQCNUNCYVXBTF-UHFFFAOYSA-N
Smiles Cl.Cl.FC1=CC=C(C=C1)C1=C(N2CCSC2=N1)C1=CC=NC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SKF 86002 dihydrochloride

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参考文献 for SKF 86002 dihydrochloride

参考文献是支持产品生物活性的出版物。

Griswold et al (1987) SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem.Pharmacol. 36 3463 PMID: 2823821

Lee et al (1994) A protein kinase involved in the regulaton of inflammatory cytokine biosynthesis. Nature 372 739 PMID: 7997261

Nick et al (1997) Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP. J.Clin.Invest. 99 975 PMID: 9062356

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关键词: SKF 86002 dihydrochloride, SKF 86002 dihydrochloride supplier, p38, MAP, kinases, inhibitors, inhibits, anti-inflammatory, agent, human, monocyte, IL-1, TNF-α, TNF-alpha, production, Mitogen-Activated, Protein, Kinase, MAPK, Signaling, Signalling, Interleukins, Tumor, Necrosis, Factor-α, Factor-alpha, Cytokines, SKF86002, dihydrochl, 2008, Tocris Bioscience

1 篇 SKF 86002 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SKF 86002 dihydrochloride 的部分引用包括：

Haas et al (2013) The inflammatory kinase MAP4K4 promotes reactivation of Kaposi's sarcoma herpesvirus and enhances the invasiveness of infected endothelial cells. PLoS Pathog 9 e1003737 PMID: 24244164

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for SKF 86002 dihydrochloride

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.