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SLU-PP-332

Cat. No. 8112 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent pan-ERR agonist
化学名： (E)-4-Hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SLU-PP-332

SLU-PP-332 is a potent and selective pan estrogen related receptor (ERR) agonist (EC50 values are 98 nM, 230 nM and 430 nM for ERRα, ERRβ and ERRγ respectively). In a mouse model of metabolic syndrome SLU-PP-332 increases energy expenditure and fatty acid oxidation, decreases fat mass, and improves insulin sensitivity. Also increases mitochondrial respiration in vitro.

技术数据 for SLU-PP-332

分子量 290.32
公式 C18H14N2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 303760-60-3
PubChem ID 5404083
InChI Key RNZIMBFHRXYRLL-XDHOZWIPSA-N
Smiles O=C(C1=CC=C(C=C1)O)N/N=C/C2=CC3=C(C=CC=C3)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SLU-PP-332

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 29.03 100

制备储备液 for SLU-PP-332

以下数据基于产品分子量 290.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.44 mL 17.22 mL 34.44 mL
5 mM 0.69 mL 3.44 mL 6.89 mL
10 mM 0.34 mL 1.72 mL 3.44 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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参考文献 for SLU-PP-332

参考文献是支持产品生物活性的出版物。

Billon et al (2023) Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity. ACS Chem.Biol. 18 756 PMID: 36988910

Billon et al (2024) A synthetic ERR agonist alleviates metabolic syndrome. J.Pharmacol.Exp.Ther. 388 232 PMID: 37739806

If you know of a relevant reference for SLU-PP-332, please let us know.

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关键词: SLU-PP-332, SLU-PP-332 supplier, SLUPP332, ERR, estrogen, related, receptor, receptors, agonist, agonists, ERRalpha, beta, gamma, mitochondrial, respiration, metabolic, syndrome, obesity, insulin, sensitivity, Estrogen, and, Related, Receptors, 8112, Tocris Bioscience

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Pathways for SLU-PP-332

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.