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Submit ReviewSM-21 maleate
说明： Presynaptic cholinergic modulator
化学名： (±)-Tropanyl 2-(4-chlorophenoxy)butanoate maleate
纯度： ≥99% (HPLC)
生物活性 for SM-21 maleate
SM-21 maleate is a potent and selective σ2 antagonist with central effects following systemic administration. Causes increased release of acetylcholine at central muscarinic synapses. Potent analgesic (efficacy comparable to morphine) and nootropic agent.
技术数据 for SM-21 maleate
| 分子量 | 453.92 |
| 公式 | C18H24ClNO3.C4H4O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 155059-42-0 |
| PubChem ID | 11691005 |
| InChI Key | BHXGTFUQDGMXHA-BTJKTKAUSA-N |
| Smiles | OC(=O)\C=C/C(O)=O.CCC(OC1=CC=C(Cl)C=C1)C(=O)OC1CC2CCC(C1)N2C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SM-21 maleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.35 | 25 |
制备储备液 for SM-21 maleate
以下数据基于产品分子量 453.92。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 8.81 mL | 44.06 mL | 88.12 mL |
| 1.25 mM | 1.76 mL | 8.81 mL | 17.62 mL |
| 2.5 mM | 0.88 mL | 4.41 mL | 8.81 mL |
| 12.5 mM | 0.18 mL | 0.88 mL | 1.76 mL |
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产品说明书 for SM-21 maleate
参考文献 for SM-21 maleate
参考文献是支持产品生物活性的出版物。
Ghelardini et al (1997) Antinociceptive profile of 3-α-tropanyl-(2-Cl)-acid phenoxybutyrate (SM-21): a novel analgesic with a presynaptic cholinergic mechanism of action. J.Pharmacol.Exp.Ther. 282 430 PMID: 9223584
Ghelardini et al (2000) Pharmacological identification of SM-21, the novel σ2 antagonist. Pharmacol.Biochem.Behav. 67 659 PMID: 11164098
Matsumoto and Mack (2001) (±)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur.J.Pharmacol. 417 R1 PMID: 11301071
If you know of a relevant reference for SM-21 maleate, please let us know.
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关键词: SM-21 maleate, SM-21 maleate supplier, Selective, σ2, sigma2, receptors, antagonists, Presynaptic, cholinergic, modulators, Muscarinic, Acetylcholine, release, Nicotinic, nAChR, Other, Sigma2, Receptors, Non-selective, Muscarinics, 0751, Tocris Bioscience
3 篇 SM-21 maleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SM-21 maleate 的部分引用包括：
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
Ishima and Hashimoto (2012) Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of σ-1 and IP3 receptors. J Diabetes Res 7 e37989 PMID: 22655093
Matsumoto et al (2007) Effects of UMB24 and (+/-)-SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice. PLoS One 86 86 PMID: 17241657
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.