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Submit ReviewSNAP 5089
Discontinued Product
2398 has been discontinued.
View all Adrenergic α<sub>1</sub> Receptors products.
说明： Subtype-selective α1A antagonist
化学名： 5-[[[3-(4,4-Diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride
纯度： ≥98% (HPLC)
生物活性 for SNAP 5089
SNAP 5089 is a subtype-selective α1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (Kivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.
技术数据 for SNAP 5089
| 分子量 | 645.19 |
| 公式 | C36H40N4O5.HCl |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 157066-77-8 |
| PubChem ID | 56972175 |
| InChI Key | MXELDPKESKXREN-UHFFFAOYSA-N |
| Smiles | CC1=C(C(OC)=O)C(C2=CC=C([N+]([O-])=O)C=C2)C(C(NCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)=C(C)N1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SNAP 5089
参考文献 for SNAP 5089
参考文献是支持产品生物活性的出版物。
Wetzel et al (1995) Discovery of α1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182
Leonardi et al (1997) Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15-2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, Part I. J.Pharmacol.Exp.Ther. 281 1272 PMID: 9190863
Kava et al (1998) α1L-adrenceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man. Br.J.Pharmacol. 123 1359 PMID: 9579731
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关键词: SNAP 5089, SNAP 5089 supplier, Subtype, selective, α1A-adrenoceptor, alpha1A-adrenoceptors, a1a-adrenoceptors, α1a-adrenergic, alpha1a-adrenergic, a1a-adrenergic, antagonists, Receptors, SNAP5089, Adrenergic, Alpha-1, 2398, Tocris Bioscience
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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.