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说明： A stable analog of endogenous S-nitroso compounds
化学名： (S)-Nitroso-N-acetylpenicillamine
生物活性 for SNAP
SNAP is a stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t½ of 37h.
技术数据 for SNAP
| 分子量 | 220.24 |
| 公式 | C7H12N2O4S |
| 储存 | Store at -20°C |
| CAS Number | 79032-48-7 |
| PubChem ID | 5231 |
| InChI Key | ZIIQCSMRQKCOCT-UHFFFAOYSA-N |
| Smiles | O=NSC(C)(C)C(NC(C)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SNAP
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 22.02 | 100 |
制备储备液 for SNAP
以下数据基于产品分子量 220.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.54 mL | 22.7 mL | 45.41 mL |
| 5 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 10 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.91 mL |
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产品说明书 for SNAP
参考文献 for SNAP
参考文献是支持产品生物活性的出版物。
Bauer and Fung (1991) Differential thermodynamic effects and tolerance properties of nitrogly. and S-nitrosothiol in experimental heart failure. J.Pharmacol.Exp.Ther. 256 249 PMID: 1899118
Cross et al (1994) Neurotoxicity in conscious rats following intraventricular SNAP, a nitric oxide donor. Neuropharmacology 33 915 PMID: 7969812
Ekblad and Sundler (1997) Motor responses in rat ileum evoked by nitric oxide donors vs. field stimulation: modulation by pituitary adenylate cyclase-activating peptide, forskolin and guanylate cyclase inhibitors. J.Pharmacol.Exp.Ther. 283 23 PMID: 9336304
Ferrero et al (1999) Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production. Br.J.Pharmacol. 127 779 PMID: 10401570
If you know of a relevant reference for SNAP, please let us know.
关键词: SNAP, SNAP supplier, stable, endogenous, S-nitroso, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, /, 0598, Tocris Bioscience
10 篇 SNAP 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SNAP 的部分引用包括：
Rodríguez-Muñoz et al (2011) NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor. Antioxid Redox Signal 14 2413 PMID: 21235400
Cheng et al (2011) Biphasic effect of nitric oxide on the cardiac voltage-dependent anion channel. FEBS Lett 585 328 PMID: 21156174
Fedele et al (1996) In vivo microdialysis study of a specific inhibitor of soluble guanylyl cyclase on the glutamate receptor/nitric oxide/cyclic GMP pathway. Br J Pharmacol 119 590 PMID: 8894183
Sachs et al (2004) Peripheral analgesic blockade of hypernociception: activation of arginine/NO/cGMP/protein kinase G/ATP-sensitive K+ channel pathway. Proc Natl Acad Sci U S A 101 3680 PMID: 14990791
Nistri et al (2002) High-Yield Method for Isolation and Culture of Endothelial Cells from Rat Coronary Blood Vessels Suitable for Analysis of Intracellular Calcium and Nitric Oxide Biosynthetic Pathways. Evid Based Complement Alternat Med 4 32 PMID: 12734571
Huang and Hsu (2010) Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex 20 982 PMID: 19666830
Polter (2017) Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapsesfollowing acute stress Elife 6 e23786 PMID: 28402252
Sunters et al (2010) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of Ins-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-i J Biol Chem 285 8743 PMID: 20042609
Yang (2007) Modulation of inhibitory activity by nitric oxide in the thalamus. J Neurophysiol 97 3386 PMID: 17376843
Sánchez et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from Ins-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol 171 5682 PMID: 25091502
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SNAP 的评论
平均评分: 5 (Based on 1 Review.)
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JNK-dependent rescue of LTPGABA by acute norBNI.
By
Anonymous on 03/18/2020
分析类型： In Vivo
种属： Rat
细胞系/组织： brain
IPSCs used before and 15 min after drug application (SNAP, 400 µM)
