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Submit ReviewSNC 162
说明： Potent, selective non-peptide δ agonist
化学名： 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
纯度： ≥98% (HPLC)
生物活性 for SNC 162
SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.
技术数据 for SNC 162
| 分子量 | 419.61 |
| 公式 | C27H37N3O |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 178803-51-5 |
| PubChem ID | 6604878 |
| InChI Key | WGIDFDFAOQVAHY-UFPGJGBJSA-N |
| Smiles | [H][C@@](C2=CC=CC=C2)(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C1=CC=C(C(N(CC)CC)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for SNC 162
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. HCl | 41.96 | 100 |
制备储备液 for SNC 162
以下数据基于产品分子量 419.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.83 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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产品说明书 for SNC 162
参考文献 for SNC 162
参考文献是支持产品生物活性的出版物。
Calderon et al (1997) Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-< J.Med.Chem. 40 695 PMID: 9057856
Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189
Negus et al (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 286 362 PMID: 9655881
If you know of a relevant reference for SNC 162, please let us know.
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关键词: SNC 162, SNC 162 supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC162, Delta, Opioid, 1529, Tocris Bioscience
2 篇 SNC 162 的引用文献
引用文献是使用了 Tocris 产品的出版物。 SNC 162 的部分引用包括：
Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Cell Cycle 6 167 PMID: 26617570
Parenty et al (2008) CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J 412 245 PMID: 18307412
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