SNC 162

Pricing Availability   Qty
说明: Potent, selective non-peptide δ agonist
化学名: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
纯度: ≥98% (HPLC)
说明书
引用文献 (2)
评论
文献 (2)

生物活性 for SNC 162

SNC 162 is a potent and selective non-peptide δ-opioid receptor agonist (Ki = 0.63 nM). Displays > 8000-fold selectivity over μ-opioid receptors and is centrally active following systemic administration in vivo.

技术数据 for SNC 162

分子量 419.61
公式 C27H37N3O
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 178803-51-5
PubChem ID 6604878
InChI Key WGIDFDFAOQVAHY-UFPGJGBJSA-N
Smiles [H][C@@](C2=CC=CC=C2)(N3C[C@@H](C)N(CC=C)C[C@@H]3C)C1=CC=C(C(N(CC)CC)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SNC 162

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. HCl 41.96 100

制备储备液 for SNC 162

以下数据基于产品分子量 419.61。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.92 mL 23.83 mL
5 mM 0.48 mL 2.38 mL 4.77 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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参考文献 for SNC 162

参考文献是支持产品生物活性的出版物。

Calderon et al (1997) Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective δ agonist (+)-4-[(αR)-α-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-< J.Med.Chem. 40 695 PMID: 9057856

Knapp et al (1996) Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. J.Pharmacol.Exp.Ther. 277 1284 PMID: 8667189

Negus et al (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J.Pharmacol.Exp.Ther. 286 362 PMID: 9655881


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查看全部 δ Opioid Receptor Agonists

关键词: SNC 162, SNC 162 supplier, Potent, selective, non-peptide, δ-opioid, delta-opioid, agonists, DOP, Receptors, OP1, SNC162, Delta, Opioid, 1529, Tocris Bioscience

2 篇 SNC 162 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SNC 162 的部分引用包括:

Parenty et al (2008) CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J 412 245 PMID: 18307412

Levoye et al (2015) A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate. Cell Cycle 6 167 PMID: 26617570


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