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SNIPER(ER)-87

Cat. No. 7120 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective ERα Degrader (SNIPER)
化学名： (2S)-N-[(1S)-1-Cyclohexyl-2-[(2S)-2-[4-[3-[[14-[4-[1-(4-hydroxyphenyl)-2-phenyl-1-buten-1-yl]phenoxy]-12-methyl-11-oxo-3,6,9-trioxa-12-azatetradec-1-yl]oxy]benzoyl]-2-thiazolyl]-1-pyrrolidinyl]-2-oxoethyl]-2-(methylamino)propanamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SNIPER(ER)-87

SNIPER(ER)-87 is a potent and selective estrogen receptor α (ERα) Degrader (Specific and Nongenetic IAP-dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER)-87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen-binding moiety 4-hydroxytamoxifen (Cat. No. 3412). The product decreases ERα levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER)-87 also reduces ERα levels and inhibits tumor proliferation in breast cancer xenograft mouse models. ER alpha/NR3A1 antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF 5715 and MAB57151.

技术数据 for SNIPER(ER)-87

分子量 1044.32
公式 C59H73N5O10S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2222354-91-6
PubChem ID 155563319
InChI Key ILLYWIKUEZHTSD-RJFLEHBVSA-N
Smiles CC/C(C1=CC=CC=C1)=C(C2=CC=C(C=C2)OCCN(C(COCCOCCOCCOC3=CC(C(C4=CSC([C@@H]5CCCN5C([C@H](C6CCCCC6)NC([C@@H](NC)C)=O)=O)=N4)=O)=CC=C3)=O)C)\C7=CC=C(C=C7)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SNIPER(ER)-87

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 104.43 100

制备储备液 for SNIPER(ER)-87

以下数据基于产品分子量 1044.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.96 mL 4.79 mL 9.58 mL
5 mM 0.19 mL 0.96 mL 1.92 mL
10 mM 0.1 mL 0.48 mL 0.96 mL
50 mM 0.02 mL 0.1 mL 0.19 mL

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参考文献 for SNIPER(ER)-87

参考文献是支持产品生物活性的出版物。

Ohoka et al (2017) In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 292 4556 PMID: 28154167

If you know of a relevant reference for SNIPER(ER)-87, please let us know.

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关键词: SNIPER(ER)-87, SNIPER(ER)-87 supplier, estrogen, receptor, alpha, alfa, ERa, ER, SNIPER, Specific, and, Nongenetic, IAP-dependent, Protein, Erasers, Degrader, degrades, Targeted, protein, degradation, TPD, XIAP, inhibitor, of, apoptosis, Estrogen, Related, Receptors, Receptor, Degraders, 7120, Tocris Bioscience

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该领域的文献

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia