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SNS 032

Cat. No. 4075 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Cdk inhibitor; potently inhibits cdk2, cdk7 and cdk9
别名： BMS-387032
化学名： N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SNS 032

SNS 032 is a cyclin dependent kinase (cdk) inhibitor (reported IC50 values are 0.004 - 0.048, 0.0045 - 0.05, 0.062 - 0.29, 0.2-0.48, 0.4 and 0.45 μM for cdk9, cdk2, cdk7, cdk1, cdk5 and cdk4, respectively). Displays no activity against 190 additional kinases (IC50 >1 μM). Arrests the cell cycle at G2/M; inhibits transcription, proliferation and colony formation, and induces apoptosis in RPMI-8226 multiple myeloma cells. Prevents tumor cell-induced VEGF secretion and in vitro angiogenesis.

技术数据 for SNS 032

分子量 380.53
公式 C17H24N4O2S2
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 345627-80-7
PubChem ID 3025986
InChI Key OUSFTKFNBAZUKL-UHFFFAOYSA-N
Smiles CC(C)(C)C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SNS 032

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 19.03 50

制备储备液 for SNS 032

以下数据基于产品分子量 380.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.5 mM 5.26 mL 26.28 mL 52.56 mL
2.5 mM 1.05 mL 5.26 mL 10.51 mL
5 mM 0.53 mL 2.63 mL 5.26 mL
25 mM 0.11 mL 0.53 mL 1.05 mL

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关键词: SNS 032, SNS 032 supplier, SNS032, inhibits, cyclin-depndent, kinase, Cdk, potent, inhibitors, cdk2, cdk7, cdk9, BMS387032, BMS, 387032, BMS-387032, Cyclin-dependent, Kinase, Non-selective, CDKs, 4075, Tocris Bioscience

2 篇 SNS 032 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SNS 032 的部分引用包括：

Cheung et al (2024) Anti-EGFR antibody-drug conjugate carrying an inhibitor targeting CDK restricts triple-negative breast cancer growth. Clin.Cancer Res. PMID: 38772416

Zhang et al (2015) Regulation and function of phosphorylation on VP8, the major tegument protein of bovine herpesvirus 1. PLoS One 89 4598 PMID: 25673708

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