SNX 482

Name: SNX 482
Brand: Tocris Bioscience
SKU: 2945

Cat. No. 2945 7 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2945 has been discontinued.

View all Ca<sub>V</sub>2.x Channels products.

说明： Potent and selective Ca_V2.3 blocker

说明书

引用文献 (7)

生物活性技术数据说明书参考文献

生物活性 for SNX 482

SNX 482 is a potent and selective, voltage-dependent R-type Ca_V2.3 calcium channel blocker (IC₅₀ = 30 nM). Antinociceptive; inhibits nociceptive C-fibre and Aδ-fibre-evoked neuronal responses.

技术数据 for SNX 482

分子量	4495.01
公式	C₁₉₂H₂₇₄N₅₂O₆₀S₇
序列	GVDKAGCRYMFGGCSVNDDCCPRLGCHSLFSYCAWDLTFSD (Modifications: Disulfide bridge between 7 - 21, 14 - 26, 20 - 33)
储存	Desiccate at -20°C
CAS Number	203460-30-4
PubChem ID	90488787
InChI Key	NSUPRLHDCFNOKD-UHFFFAOYSA-N
Smiles	[H]NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC4=CNC=N4)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CCCNC(N)=N)NC1=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C2=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SNX 482

分析证书/产品说明书

化学品安全技术说明书

参考文献 for SNX 482

参考文献是支持产品生物活性的出版物。

Newcomb et al (1998) Selective peptide antagonist of the class E calcium channel from the venom of the Tarantula Hysterocrates gigas. Biochemistry 37 15353 PMID: 9799496

Bourinet et al (2001) Interaction of SNX482 with domains III and IV inhibits activation gating of α_1E (Ca_V2.3) calcium channels. Biophys.J. 81 79 PMID: 11423396

Matthews et al (2007) The Ca_V2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur.J.Neurosci. 25 3561 PMID: 17610575

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