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Submit ReviewSodium butyrate
说明： Histone deacetylase inhibitor
化学名： Butanoic acid sodium salt
生物活性 for Sodium butyrate
Sodium butyrate is a histone deacetylase inhibitor (HDAC). Sodium butyrate restores contextual memory in a transgenic mouse model of Alzheimer's disease. In a transgenic mouse model of Huntington's disease, sodium butyrate ameliorates the neurodegenerative phenotype and extends survival. Sodium butyrate induces pancreatic progenitor formation, and directs the differentiation of mouse embryonic stem cells into hepatocytes when used in combination with the cytokine Activin A. Sodium butyrate also augments transcription factor stimulated iPSC generation. In hepatocellular carcinoma cells, Sodium butyrate downregulates expression of c-Myc resulting in decreased hexokinase 2 levels, inhibition of aerobic glycolysis and reduced cell growth.
技术数据 for Sodium butyrate
| 分子量 | 110.09 |
| 公式 | C4H7NaO2 |
| 储存 | Store at RT |
| CAS Number | 156-54-7 |
| PubChem ID | 5222465 |
| InChI Key | MFBOGIVSZKQAPD-UHFFFAOYSA-M |
| Smiles | [Na+].CCCC([O-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Sodium butyrate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 11.01 | 100 |
制备储备液 for Sodium butyrate
以下数据基于产品分子量 110.09。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 9.08 mL | 45.42 mL | 90.83 mL |
| 5 mM | 1.82 mL | 9.08 mL | 18.17 mL |
| 10 mM | 0.91 mL | 4.54 mL | 9.08 mL |
| 50 mM | 0.18 mL | 0.91 mL | 1.82 mL |
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产品说明书 for Sodium butyrate
参考文献 for Sodium butyrate
参考文献是支持产品生物活性的出版物。
Boffa et al (1978) Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J.Biol.Chem. 253 3364 PMID: 649576
Kilgore et al (2010) Inhibitors of class 1 histone deacetylases reverse contextual deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35 870 PMID: 20010553
Ren et al (2010) Effects of sodium butyrate on the differentiation of pancreatic and hepatic progenitor cells from mouse embryonic stem cells. J.Cell Biochem. 109 236 PMID: 19911386
Zhou et al (2010) Differentiation of mouse embryonic stem cells into hepatocytes induced by a combination of cytokines and sodium butyrate. J.Cell Biochem. 109 606 PMID: 20039312
Liang et al (2010) Butyrate promotes induced pluripotent stem cell generation. J.Biol.Chem. 285 25516 PMID: 20554530
Ferrante et al (2003) Histone deacetylase inhibition by sodium butyrate chemotherapy ameliorates the neurodegenerative phenotype in Huntington's disease mice. J.Neurosci. 23 9418 PMID: 14561870
Yu et al (2022) Sodium butyrate inhibits aerobic glycolysis of hepatocellular carcinoma cells via the c-myc/hexokinase 2 pathway. J.Cell.Mol.Med. 26 3031 PMID: 35429101
If you know of a relevant reference for Sodium butyrate, please let us know.
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关键词: Sodium butyrate, Sodium butyrate supplier, Histone, deacetylase, inhibitors, inhibits, differentiation, progenitors, ESC, HDACs, stem, cells, epigenetics, Huntingtons, Alzheimers, neurodegeneration, Hepatocyte, Stem, Cells, Non-selective, Non-Selective, 3850, Tocris Bioscience
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Acetylation assay.
By
Xiaoyu Zhang on 03/07/2024
分析类型： In Vitro
种属： Human
5mM sodium butyrate added to in vitro acetylation assay buffer.Western Blot to detect histone acetylation. Lane1 is control. Lane 2 is treatment. It showed acetylation unregulated after treatment.
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