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Submit ReviewSodium Cromoglicate
说明： Promotes ESCs/iPSCs differentiation into pancreatic endocrine islet cells
化学名： 5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt
纯度： ≥98% (HPLC)
生物活性 for Sodium Cromoglicate
Sodium Cromoglicate is a promotes transformation ESCs/iPSCs into pancreatic endocrine islet cells. Facilitates differentiation from endocrine precursors. Also inhibits mast cell degranulation and histamine release. Antiasthmatic.
技术数据 for Sodium Cromoglicate
| 分子量 | 512.33 |
| 公式 | C23H14Na2O11 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 15826-37-6 |
| PubChem ID | 27503 |
| InChI Key | VLARUOGDXDTHEH-UHFFFAOYSA-L |
| Smiles | OC(COC1=C2C(C=C(C(O[Na])=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O[Na])=O)OC4=CC=C3)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Sodium Cromoglicate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 25.62 | 50 |
制备储备液 for Sodium Cromoglicate
以下数据基于产品分子量 512.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.9 mL | 19.52 mL | 39.04 mL |
| 2.5 mM | 0.78 mL | 3.9 mL | 7.81 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.9 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.78 mL |
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产品说明书 for Sodium Cromoglicate
参考文献 for Sodium Cromoglicate
参考文献是支持产品生物活性的出版物。
Orr and Cox (1969) Disodium Cromoglycate, an inhibitor of mast cell degranulation and histamine release induced by phospholipase A. Nature. 223 197 PMID: 4183038
Kondo et al (2017) Identification of a small molecule that facilitates the differentiation of human iPSCS/ESCs and mouse embryonic pancreatic explants into pancreatic endocrine cells. Diabetologia. 60 1454 PMID: 28534195
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关键词: Sodium Cromoglicate, Sodium Cromoglicate supplier, sodium, cromoglicate, cromoglycate, differentiation, pancreatic, islet, cells, mast, cell, degranulation, histamine, anti-asthmatic, ESCs, and, iPSC, Histaminergic-Related, Compounds, 6424, Tocris Bioscience
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该领域的文献
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
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