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说明： Activator of hFFA2-DREADDs
化学名： (2E,4E)-2,4-Hexenoic acid
纯度： ≥98% (HPLC)
生物活性 for Sorbic acid
Sorbic acid is an activator of hFFA2-DREADDs. Inhibits forskolin-induced cAMP production (IC50 ∼ 1 μM) and promotes accumulation of inositol monophosphates (IC50 >1 μM) in cells expressing hFFA2-DREADD. Promotes the release of GLP-1 from colonic crypts derived from hFFA2-DREADD-expressing mice.
技术数据 for Sorbic acid
| 分子量 | 112.13 |
| 公式 | C6H8O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 110-44-1 |
| PubChem ID | 643460 |
| InChI Key | WSWCOQWTEOXDQX-MQQKCMAXSA-N |
| Smiles | CC=CC=CC(=O)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Sorbic acid
参考文献 for Sorbic acid
参考文献是支持产品生物活性的出版物。
Bolognini et al (2019) Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nat.Chem.Biol. 15 489 PMID: 30992568
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.