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Submit ReviewSotalol hydrochloride
说明： β antagonist
化学名： N-[4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]phenyl]methanesulfonamide hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Sotalol hydrochloride
Sotalol hydrochloride is a relatively potent pure β adrenergic antagonist, unique in possessing additional class III antiarrhythmic activity.
技术数据 for Sotalol hydrochloride
| 分子量 | 308.82 |
| 公式 | C12H20N2O3S.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 959-24-0 |
| PubChem ID | 66245 |
| InChI Key | VIDRYROWYFWGSY-UHFFFAOYSA-N |
| Smiles | Cl.CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Sotalol hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 15.44 | 50 |
制备储备液 for Sotalol hydrochloride
以下数据基于产品分子量 308.82。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.48 mL | 32.38 mL | 64.76 mL |
| 2.5 mM | 1.3 mL | 6.48 mL | 12.95 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 25 mM | 0.13 mL | 0.65 mL | 1.3 mL |
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产品说明书 for Sotalol hydrochloride
参考文献 for Sotalol hydrochloride
参考文献是支持产品生物活性的出版物。
Claudel and Touboul (1995) Sotalol: from 'just another beta blocker' to 'the prototype class III antidysrhythmic compound'. Pacing Clin.Electrophysiol. 18 451 PMID: 7770366
Fiset et al (1997) Block of Iks by the diuretic agent indap. modulates cardiac electrophysiological effects of the class III antiarrhythmic drug dl-sotalol. J.Pharmacol.Exp.Ther. 283 148 PMID: 9336319
Uloth et al (1966) Sulfonanilides. I. Monoalkyl- and arylsulfonamidophenethanolamines. J.Med.Chem. 9 88 PMID: 6006227
Merck Index 12 8876
If you know of a relevant reference for Sotalol hydrochloride, please let us know.
关键词: Sotalol hydrochloride, Sotalol hydrochloride supplier, β-adrenoceptor, beta-adrenoceptors, b-adrenergic, β-adrenergic, beta-adrenergic, b-adrenoceptors, antagonists, Receptors, Non-Selective, Non-selective, Adrenergic, Beta, 0952, Tocris Bioscience
3 篇 Sotalol hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Sotalol hydrochloride 的部分引用包括：
McKeithan et al (2017) An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol 8 766 PMID: 29075196
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. J Neurosci 329 350 PMID: 19144685
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
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该领域的文献
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Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.