Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSpaglumic acid
Discontinued Product
0391 has been discontinued.
View all Glutamate (Metabotropic) Group II Receptors products.
说明： Selective mGlu3 agonist
别名： α-NAAG
化学名： N-Acetyl-L-aspartyl-L-glutamic acid
纯度： ≥96% (HPLC)
生物活性 for Spaglumic acid
The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
技术数据 for Spaglumic acid
| 分子量 | 304.26 |
| 公式 | C11H16N2O8 |
| 储存 | Store at -20°C |
| 纯度 | ≥96% (HPLC) |
| CAS Number | 3106-85-2 |
| PubChem ID | 188803 |
| InChI Key | OPVPGKGADVGKTG-BQBZGAKWSA-N |
| Smiles | CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Spaglumic acid
参考文献 for Spaglumic acid
参考文献是支持产品生物活性的出版物。
Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443 PMID: 10899918
Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16 PMID: 10991955
Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174 PMID: 9202308
按标靶查看相关产品
关键词: Spaglumic acid, Spaglumic acid supplier, Putative, endogenous, neurotransmitter, Selective, mGlu3, agonists, Glutamate, mGlur, Receptors, Metabotropic, Group, II, iGluR, Ionotropic, alpha-NAAG, NAAG, a-NAAG, (Metabotropic), Miscellaneous, 0391, Tocris Bioscience
2 篇 Spaglumic acid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Spaglumic acid 的部分引用包括：
Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496 PMID: 19383832
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Spaglumic acid 的评论
目前没有该产品的评论。 Be the first to review Spaglumic acid and earn rewards!
Have you used Spaglumic acid?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.