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Submit ReviewSpermine tetrahydrochloride
说明： Modulator at polyamine site
化学名： N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
生物活性 for Spermine tetrahydrochloride
Spermine tetrahydrochloride is a polyamine which produces a variety of modulatory effects on the NMDA receptor channel, acting through a specific site on the complex which can cause both agonist and antagonist effects.
技术数据 for Spermine tetrahydrochloride
| 分子量 | 348.19 |
| 公式 | C10H26N4.4HCl |
| 储存 | Desiccate at +4°C |
| CAS Number | 306-67-2 |
| PubChem ID | 9384 |
| InChI Key | XLDKUDAXZWHPFH-UHFFFAOYSA-N |
| Smiles | NCCCNCCCCNCCCN.Cl.Cl.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Spermine tetrahydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 34.82 | 100 |
制备储备液 for Spermine tetrahydrochloride
以下数据基于产品分子量 348.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.87 mL | 14.36 mL | 28.72 mL |
| 5 mM | 0.57 mL | 2.87 mL | 5.74 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.87 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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产品说明书 for Spermine tetrahydrochloride
参考文献 for Spermine tetrahydrochloride
参考文献是支持产品生物活性的出版物。
Benveniste and Mayer (1993) Multiple effects of spermine on N-MthD.-aspartic acid receptor responses of rat cultured hippocampal neurones. J.Physiol. 464 131 PMID: 8229795
Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557
Johnson (1996) Modulation of channel function by polyamines. TiPS 17 22 PMID: 8789355
Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608
If you know of a relevant reference for Spermine tetrahydrochloride, please let us know.
关键词: Spermine tetrahydrochloride, Spermine tetrahydrochloride supplier, modulators, polyamine, site, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, 0958, Tocris Bioscience
8 篇 Spermine tetrahydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Spermine tetrahydrochloride 的部分引用包括：
Kim and Cho (2017) Encoding of Discriminative Fear Memory by Input-Specific LTP in the Amygdala. Neuron 95 1129 PMID: 28823727
Campioni et al (2009) Stress-induced changes in nucleus accumbens glutamate synaptic plasticity. J Neurosci 101 3192 PMID: 19357347
Soto et al (2009) Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5. Nat Neurosci 12 277 PMID: 19234459
Quintana et al (2015) Acid-sensing ion channel 1a drives AMPA receptor plasticity following ischaemia and acidosis in hippocampal CA1 neurons. Proc Natl Acad Sci U S A 593 4373 PMID: 26174503
Biase et al (2011) NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination. J Physiol 31 12650 PMID: 21880926
McGee et al (2015) Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. J Neurosci 35 16171 PMID: 26658868
Soto et al (2014) Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors. J Neurosci 34 11673 PMID: 25164663
Zonouzi et al (2011) Bidirectional plasticity of calcium-permeable AMPA receptors in oligodendrocyte lineage cells. Nat Neurosci 14 1430 PMID: 21983683
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