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Submit ReviewSpiperone hydrochloride
说明： 5-HT2A antagonist; also D2-like antagonist
化学名： 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Spiperone hydrochloride
Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.
技术数据 for Spiperone hydrochloride
| 分子量 | 431.94 |
| 公式 | C23H26FN3O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2022-29-9 |
| PubChem ID | 11957687 |
| InChI Key | QUIKMLCZZMOBLH-UHFFFAOYSA-N |
| Smiles | Cl.FC1=CC=C(C=C1)C(=O)CCCN1CCC2(CC1)N(CNC2=O)C1=CC=CC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Spiperone hydrochloride
参考文献 for Spiperone hydrochloride
参考文献是支持产品生物活性的出版物。
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Seeman and van Tol (1994) DA receptor pharmacology. TiPS 15 264 PMID: 7940991
Merck Index 12 8903
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关键词: Spiperone hydrochloride, Spiperone hydrochloride supplier, D2-like, antagonists, 5-HT2A, Dopamine, Non-Selective, Receptors, Serotonin, dopaminergic, Non-selective, 0995, Tocris Bioscience
6 篇 Spiperone hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Spiperone hydrochloride 的部分引用包括：
Nickla et al (2010) DArgic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks. Exp Eye Res 91 715 PMID: 20801115
Meredith et al (2006) DA targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma. Proc Natl Acad Sci U S A 103 13485 PMID: 16938864
Zapata et al (2007) Regulation of DA transporter function and cell surface expression by D3 DA receptors. J Biol Chem 282 35842 PMID: 17923483
Walory et al (2018) Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands. Int J Mol Sci 19 PMID: 30347827
Baca et al (2013) Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice. Brain Res 1532 85 PMID: 23939223
Titlow et al (2013) Pharmacological analysis of DA modulation in the Drosophila melanogaster larval heart. Physiol Rep 1 e00020 PMID: 24303109
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.