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SR 1001

Cat. No. 4868 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4868 has been discontinued.

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说明： RORα/γ inverse agonist
化学名： N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 说明书 参考文献

生物活性 for SR 1001

Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.

许可信息

Sold under license from The Scripps Research Institute.

技术数据 for SR 1001

分子量 477.4
公式 C15H13F6N3O4S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1335106-03-0
PubChem ID 44241473
InChI Key OZBSSKGBKHOLGA-UHFFFAOYSA-N
Smiles CC1=C(S(NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2)(=O)=O)SC(NC(C)=O)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for SR 1001

参考文献是支持产品生物活性的出版物。

Solt et al (2011) Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature 472 491 PMID: 21499262

Crumbley et al (2012) Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS ONE 7 33804 PMID: 22485150

Beurel et al (2013) Inflammatory T helper 17 cells promote depression-like behavior in mice. Biol.Psychiatry 73 622 PMID: 23174342

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关键词: SR 1001, SR 1001 supplier, SR1001, retinoic, acid, receptor-related, orphan, receptor, RORα, RORalpha, RORa, RORgamma, RORγ, RORg, inverse, agonists, Retinoic, Acid-related, Orphan, Receptors, 4868, Tocris Bioscience

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