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SR 10067

Cat. No. 6038 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective Rev-Erbα/β agonist; anxiolytic
化学名： [3-[[4-(1,1-Dimethylethoxy)phenoxy]methyl]-3,4-dihydro-2(1H)-isoquinolinyl]-1-naphthalenylmethanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 10067

SR 10067 is a selective Rev-Erbα/β agonist (IC50 values are 160 and 170 nM for Rev-Erbβ and Rev-Erbα respectively). Exhibits no significant activity against a wide range of nuclear receptors, other receptors, ion channels and transporters at 20 μM. Increases wakefulness, reduces REM and slow wave sleep in vivo. Also reduces anxiety-like behavior in marble-burying assay. Cell permeable and brain penetrant.

技术数据 for SR 10067

分子量 465.58
公式 C31H31NO3
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1380548-02-6
PubChem ID 60168097
InChI Key MOPAGKWBFUICQT-UHFFFAOYSA-N
Smiles CC(C)(OC1=CC=C(C=C1)OCC2CC3=CC=CC=C3CN2C(C4=CC=CC5=C4C=CC=C5)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 10067

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 2.33 5 温和加热

制备储备液 for SR 10067

以下数据基于产品分子量 465.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.05 mM 42.96 mL 214.79 mL 429.57 mL
0.25 mM 8.59 mL 42.96 mL 85.91 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
2.5 mM 0.86 mL 4.3 mL 8.59 mL

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参考文献 for SR 10067

参考文献是支持产品生物活性的出版物。

Banerjee et al (2014) Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour. Nat.Commun. 23 5759 PMID: 25536025

Thevis et al (2016) Emerging drugs affecting skeletal muscle function and mitochondrial biogenesis - Potential implications for sports drug testing programs. Rapid Commun. Mass Spectrom 30 635 PMID: 26842585

If you know of a relevant reference for SR 10067, please let us know.

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关键词: SR 10067, SR 10067 supplier, SR10067, SR_10067, Selective, REV-ERBab, REV-ERBa, REV-ERBb, REV-ERBalpha, REV-ERBbeta, REV-ERBα/β, agonists, agonism, sleep, circadian, rhythm, anxiety, anxiolytics, Rev-Erb, Receptors, 6038, Tocris Bioscience

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