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SR 16584

Cat. No. 4424 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective α3β4 nAChR antagonist
化学名： 1,3-Dihydro-1-(3-exo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-2H-indol-2-one
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for SR 16584

SR 16584 is a selective α3β4 nAChR antagonist (IC50 = 10.2 μM). Selectively binds α3β4 over α4β2 and α7 subtypes (Ki values are 0.508, >100 and >100 μM, respectively).

技术数据 for SR 16584

分子量 270.37
公式 C17H22N2O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1150153-86-8
PubChem ID 42602880
InChI Key GIDZCNCCCWFCIN-UHFFFAOYSA-N
Smiles O=C(CC3=C2C=CC=C3)N2[C@H]1C[C@@H](N4C)CCC[C@@H]4C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for SR 16584

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.04 100

制备储备液 for SR 16584

以下数据基于产品分子量 270.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.7 mL 18.49 mL 36.99 mL
5 mM 0.74 mL 3.7 mL 7.4 mL
10 mM 0.37 mL 1.85 mL 3.7 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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产品说明书 for SR 16584

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for SR 16584

参考文献是支持产品生物活性的出版物。

Zaveri et al (2012) Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J.Med.Chem. 53 8187 PMID: 20979364

If you know of a relevant reference for SR 16584, please let us know.

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关键词: SR 16584, SR 16584 supplier, SR16584, nAChRs, nicotinic, acetylcholine, receptors, a3b4, alpha3beta4, α3β4, antagonists, Nicotinic, Receptors, (Other, Subtypes), 4424, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.