主页 / 药理学 / Ion Channels / Calcium Channels / Voltage-gated Calcium Channels (CaV) / CaV1.x Channels (L-type) / CaV1.x Channel (L-type) Blockers / SR 33805 oxalate

SR 33805 oxalate

Cat. No. 1806 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1806 has been discontinued.

View all Ca<sub>V</sub>1.x Channels (L-type) products.
说明： CaV1.x blocker; binds allosterically to distinct site
化学名： 3,4-Dimethoxy-N-methyl-N-[3-[4-[[1-methyl-3-(1-methylethyl)-1H-indol-2-yl]sulfonyl]phenoxy]propyl]benzeneethanamine
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for SR 33805 oxalate

Potent Ca2+ channel antagonist; binds allosterically to the a1-subunit of L-type Ca2+ channels (Kd = 20 pM), at a site distinct from other types of blocker. Shows some selectivity for vascular smooth muscle, inducing vasorelaxation without producing inotropic or chronotropic effects. Inhibits PDGF-stimulated smooth muscle cell proliferation.

技术数据 for SR 33805 oxalate

分子量 654.77
公式 C32H40N2O5S.C2H2O4
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 121346-33-6
PubChem ID 21256218
InChI Key MZWPPDAHWIKZID-UHFFFAOYSA-N
Smiles O=C(O)C(O)=O.O=S(C2=C(C(C)C)C1=CC=CC=C1N2C)(C3=CC=C(OCCCN(C)CCC4=CC=C(OC)C(OC)=C4)C=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for SR 33805 oxalate

分析证书/产品说明书
化学品安全技术说明书

参考文献 for SR 33805 oxalate

参考文献是支持产品生物活性的出版物。

Chatelain et al (1993) In vitro characterization of a novel Ca2+ entry blocker: SR 33805. Eur.J.Pharmacol. 246 181 PMID: 8223943

Magnier-Gaubil et al (1996) Smooth muscle cell cycle and proliferation. Relationship between calcium influx and sarco-endoplasmic reticulum Ca2+ATPase regulation. J.Biol.Chem. 271 27788 PMID: 8910375

Romey and Lazdunski (1994) Effects of a new class of calcium antagonists, SR33557 (fantofarone) and SR33805, on neuronal voltage-activated Ca++ channels. J.Pharmacol.Exp.Ther. 271 1348 PMID: 7996445

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关键词: SR 33805 oxalate, SR 33805 oxalate supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, SR33805, oxalate, Cav1.x, 1806, Tocris Bioscience

1 篇 SR 33805 oxalate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 SR 33805 oxalate 的部分引用包括：

Wu et al (2008) Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity. J Neurophysiol 100 1897 PMID: 18715900

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