Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewSSYA10-001
说明： Potent coronavirus helicase inhibitor; also inhibits human papillomavirus E6
化学名： 2,4-Dihydro-5-[[(2-nitrophenyl)thio]methyl]-4-(2-propen-1-yl)-3H-1,2,4-triazole-3-thione
纯度： ≥98% (HPLC)
生物活性 for SSYA10-001
SSYA10-001 is a potent coronavirus helicase inhibitor (IC50 values are 0.046 μM and >3 μM for unwinding and ATPase, respectively). Inhibits SARS-CoV-2 Nsp13 helicase (IC50 = 3.5 μM), blocks dsDNA and dsRNA unwinding activities of Nsp13 (IC50 values are 5.3 μM and 5.7 μM respectively). In a SARS-CoV replicon assay SSYA10-001 inhibits (+) sense but not (-) sense RNA synthesis (EC50 = 8.95 μM). Also inhibits human papillomavirus E6 (IC50 = 10 μM)
技术数据 for SSYA10-001
| 分子量 | 308.37 |
| 公式 | C12H12N4O2S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 675104-49-1 |
| PubChem ID | 2807230 |
| InChI Key | VWFIHGWHMXSTAO-UHFFFAOYSA-N |
| Smiles | C=CCN1C(NN=C1CSC2=C(N(=O)=O)C=CC=C2)=S |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SSYA10-001
参考文献 for SSYA10-001
参考文献是支持产品生物活性的出版物。
Adedeji et al (2012) Severe acute respiratory syndrome coronavirus replication inhibitor that interferes with the nucleic acid unwinding of the viral helicase. Antimicrob.Agents Chemother. 56 4718 PMID: 22733076
Malecka et al (2014) Identification and characterization of small molecule human papillomavirus E6 inhibitors. ACS Chem.Biol. 9 1603 PMID: 24854633
Kumar and Lupoli (2020) Exploiting existing molecular scaffolds for long-term COVID treatment. ACS Med.Chem.Lett. 11 1357 PMID: 32665808
Spratt et al (2021) Coronavirus helicases: attractive and unique targets of antiviral drug-development and therapeutic patents. Expert Opin.Ther.Pat. 31 339 PMID: 33593200
Nizi et al (2022) Discovery of 2-phenylquinolines with broad-spectrum anti-coronavirus activity. ACS Med.Chem.Lett. 13 855 PMID: 35571875
If you know of a relevant reference for SSYA10-001, please let us know.
按标靶查看相关产品
关键词: SSYA10-001, SSYA10-001 supplier, SSYA10001, coronaviruses, helicases, inhibitors, potent, unwinding, ATPase, SARS-CoV-2, nsp13, human, papillomavirus, dsRNA, dsDNA, Coronavirus, Other, Antivirals, DNA,, RNA, and, Protein, Synthesis, 7554, Tocris Bioscience
篇 SSYA10-001 的引用文献
引用文献是使用了 Tocris 产品的出版物。
目前没有 SSYA10-001 的引用文献。 您是否知道使用了 Tocris SSYA10-001 的优秀论文？ 请告知我们.
SSYA10-001 的评论
目前没有该产品的评论。 Be the first to review SSYA10-001 and earn rewards!
Have you used SSYA10-001?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image