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Submit ReviewST 91
Discontinued Product
2638 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
说明： α2 agonist, putative α2C agonist
化学名： N-(2,6-Diethylphenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
纯度： ≥99% (HPLC)
生物活性 for ST 91
ST 91 is an α2-adrenoceptor agonist that does not cross the blood brain barrier. Displays ~ 120-fold selectivity for α2 receptors over α1 receptors and acts predominantly at non-α2A-adrenoceptors which may be of the α2C subtype. Antinociceptive; increases tail-flick latencies in Sasco and Harlan rats.
技术数据 for ST 91
| 分子量 | 253.77 |
| 公式 | C13H19N3.HCl |
| 储存 | Desiccate at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 4749-61-5 |
| PubChem ID | 20863 |
| InChI Key | ZLRWFGBEDNTMEU-UHFFFAOYSA-N |
| Smiles | CCC2=C(C(CC)=CC=C2)/N=C1NCCN/1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ST 91
参考文献 for ST 91
参考文献是支持产品生物活性的出版物。
Takano and Yaksh (1992) Characterization of the pharmacology of intrathecally administered alpha-2 agonists and antagonists in rats. J.Pharmacol.Exp.Ther. 261 764 PMID: 1349648
Celly et al (1999) Cardiopulmonary effects of the α2-adrenoceptor agonists medetomidine and ST-91 in anesthetized sheep. J.Pharmacol.Exp.Ther. 289 712 PMID: 10215644
Graham et al (2000) Synergistic interactions between two α2-adrenoceptor agonists, dexmedetom. and ST-91, in two substrains of Sprague-Dawley rats. Pain 85 135 PMID: 10692612
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关键词: ST 91, ST 91 supplier, α2-adrenoceptor, alpha2-adrenoceptors, a2-adrenoceptors, α2-Adrenergic, alpha2-Adrenergic, a2-adrenergic, agonists, putative, α2C-adrenoceptor, alpha2C-adrenoceptors, α2c-adrenergic, alpha2c-adrenergic, a2c-adrenoceptor, a2c-adrenergic, Receptors, ST, Adrenergic, Alpha-2, 2638, Tocris Bioscience
1 篇 ST 91 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ST 91 的部分引用包括：
Kim et al (2011) Icilin-evoked behavioral stimulation is attenuated by alpha2-adrenoceptor activation. Brain Res 1384 110 PMID: 21315691
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.