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说明： Endogenous lipid, active in vivo. Enhances effects of endovanilloids at TRPV1 receptors
别名： N-Stearoyldopamine
化学名： N-[2-(3,4-Dihydroxyphenyl)ethyl]octadecanamide
纯度： ≥98% (HPLC)
生物活性 for STEARDA
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).
技术数据 for STEARDA
| 分子量 | 419.64 |
| 公式 | C26H45NO3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 105955-10-0 |
| PubChem ID | 10025103 |
| InChI Key | KOCSVLPLQCBIGW-UHFFFAOYSA-N |
| Smiles | O=C(NCCC1=CC=C(O)C(O)=C1)CCCCCCCCCCCCCCCCC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for STEARDA
参考文献 for STEARDA
参考文献是支持产品生物活性的出版物。
Chu et al (2003) N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633 PMID: 12569099
De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251 PMID: 15289293
关键词: STEARDA, STEARDA supplier, Endogenous, lipid, active, vivo, Enhances, effects, endovanilloids, TRPV1, receptors, inhibitors, inhibits, 5-lipoxygenase, Vanillioid, Receptors, VR1, TRPV, TRP, Channels, Transient, Receptor, Potential, Lipoxygenase, Oxidase, Oxygenases, Oxidases, 5-LOX, N-Stearoyldopamine, 2204, Tocris Bioscience
1 篇 STEARDA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 STEARDA 的部分引用包括：
Arensdorf (2017) Sonic Hedgehog activates phospholipase A2 to enhance Smoothened ciliary translocation. Cell Rep 19 2074 PMID: 28591579
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