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Submit ReviewStemRegenin 1
说明： Aryl hydrocarbon receptor (AhR) antagonist; promotes HSC expansion and engraftment
化学名： 4-[2-[[2-Benzo[b]thien-3-yl-9-(1-methylethyl)-9H-purin-6-yl]amino]ethyl]phenol
纯度： ≥98% (HPLC)
生物活性 for StemRegenin 1
StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC50 = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.
技术数据 for StemRegenin 1
| 分子量 | 429.54 |
| 公式 | C24H23N5OS |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1227633-49-9 |
| PubChem ID | 46199207 |
| InChI Key | BGFHMYJZJZLMHW-UHFFFAOYSA-N |
| Smiles | CC(N1C=NC2=C(N=C(C3=CSC4=CC=CC=C34)N=C12)NCCC5=CC=C(C=C5)O)C |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for StemRegenin 1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 42.95 | 100 |
制备储备液 for StemRegenin 1
以下数据基于产品分子量 429.54。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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产品说明书 for StemRegenin 1
参考文献 for StemRegenin 1
参考文献是支持产品生物活性的出版物。
Jackson et al (2017) Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion. Stem Cell Res. 21 124 PMID: 28445828
Genovese et al (2014) Targeted genome editing in human repopulating haematopoietic stem cells. Nature 510 235 PMID: 24870228
Boitano et al (2010) Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science 329 1345 PMID: 20688981
Koide et al (2016) Aryl hydrocarbon receptor antagonist StemRegenin 1 promotes the expansion of human promyelocytic leukemia cell line, NB4. Anticancer Res. 36 3635 PMID: 27354634
If you know of a relevant reference for StemRegenin 1, please let us know.
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关键词: StemRegenin 1, StemRegenin 1 supplier, SR1, aryl, hydrocarbon, receptors, antagonists, antagonizes, antagonism, AHR, hematopoietic, haematopoietic, stem, cells, HSCs, CD34, expansion, engraftment, HSC, Aryl, Hydrocarbon, Receptors, Stem, Cell, Proliferation, Hematopoietic, Cells, 7086, Tocris Bioscience
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