STF 083010

Cat. No. 4509 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Inhibits IRE1α endonuclease activity

化学名： N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide

纯度： ≥98% (HPLC)

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for STF 083010

STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138⁺ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.

技术数据 for STF 083010

分子量	317.38
公式	C₁₅H₁₁NO₃S₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	307543-71-1
PubChem ID	11487816
InChI Key	RAKGNVNONBJBSW-UHFFFAOYSA-N
Smiles	OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for STF 083010

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.74	100

制备储备液 for STF 083010

以下数据基于产品分子量 317.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.15 mL	15.75 mL	31.51 mL
5 mM	0.63 mL	3.15 mL	6.3 mL
10 mM	0.32 mL	1.58 mL	3.15 mL
50 mM	0.06 mL	0.32 mL	0.63 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

产品说明书 for STF 083010

分析证书/产品说明书

化学品安全技术说明书

参考文献 for STF 083010

参考文献是支持产品生物活性的出版物。

Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713

Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465

If you know of a relevant reference for STF 083010, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 IRE1 Inhibitors

关键词: STF 083010, STF 083010 supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, inhibits, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum, IRE1, 4509, Tocris Bioscience