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Submit ReviewSTF 083010
说明： Inhibits IRE1α endonuclease activity
化学名： N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
纯度： ≥98% (HPLC)
生物活性 for STF 083010
STF 083010 is a inhibitor of IRE1α endonuclease activity; blocks endogenous XBP1 mRNA splicing. Displays cytostatic and cytotoxic effects in CD138+ multiple myeloma (MM) cells in vitro; inhibits bortezomib-induced XBP1 activity in myeloma xenografts in vivo. Does not alter IRE1α kinase activity.
技术数据 for STF 083010
| 分子量 | 317.38 |
| 公式 | C15H11NO3S2 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 307543-71-1 |
| PubChem ID | 11487816 |
| InChI Key | RAKGNVNONBJBSW-UHFFFAOYSA-N |
| Smiles | OC1=CC=C(C=CC=C2)C2=C1/C=N/S(C3=CC=CS3)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for STF 083010
参考文献 for STF 083010
参考文献是支持产品生物活性的出版物。
Papandreou et al (2011) Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood. 117 1311 PMID: 21081713
Kraskiewicz and FitzGerald (2012) InterfERing with endoplasmic reticulum stress. Trends Pharmacol.Sci. 33 53 PMID: 22112465
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关键词: STF 083010, STF 083010 supplier, STF083010, IRE1alpha, IRE1a, IRE1α, inhibitors, inhibits, endonucleases, RNases, XBP, mRNA, splicing, inositol, requiring, enzyme, endoplasmic, reticulum, IRE1, 4509, Tocris Bioscience
5 篇 STF 083010 的引用文献
引用文献是使用了 Tocris 产品的出版物。 STF 083010 的部分引用包括：
Chen et al (2018) IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation 15 32 PMID: 29394934
Ju-Ri et al (2020) IRE1α kinase-mediated unconventional protein secretion rescues misfolded CFTR and pendrin. Sci Adv 6 eaax9914 PMID: 32128399
Ko et al (2017) Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1α-dependent decay. Sci Rep 7 14940 PMID: 29097726
Xu et al (2019) The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight 4 PMID: 30843874
Kim et al (2015) Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production. Cell Death Dis 194 4498 PMID: 25821218
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Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets