主页 / 药理学 / Ion Channels / Ligand-gated Ion Channels / Purinergic (P2X) Receptors / Purinergic (P2X) Receptor Antagonists / Suramin hexasodium salt

Suramin hexasodium salt

Cat. No. 1472 24 篇引用文献 3 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Non-selective P2 antagonist
化学名： 8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfonic acid hexasodium salt
纯度： ≥98% (HPLC)
说明书
引用文献 (24)
评论 (3)
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Suramin hexasodium salt

Suramin hexasodium salt is a non-selective P2 purinergic antagonist. Also blocks calmodulin binding to recognition sites and G protein coupling to G protein-coupled receptors. Increases open probability of ryanodine receptor (RyR) channels and acts as a competitive α1β2γ2 GABAA receptor antagonist. Anticancer, antiviral and antiparasitic agent.

This product may be supplied with a high degree of hydration and some residual NaCl, the amounts of which are batch dependent. Please refer to the Certificate of Analysis to obtain the batch specific Net Product Content.

技术数据 for Suramin hexasodium salt

分子量 1429.15
公式 C51H34N6Na6O23S6
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 129-46-4
PubChem ID 5360
InChI Key VAPNKLKDKUDFHK-UHFFFAOYSA-H
Smiles [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CC1=CC=C(C=C1NC(=O)C1=CC=CC(NC(=O)NC2=CC=CC(=C2)C(=O)NC2=C(C)C=CC(=C2)C(=O)NC2=C3C(C=C(C=C3S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C2)S([O-])(=O)=O)=C1)C(=O)NC1=C2C(C=C(C=C2S([O-])(=O)=O)S([O-])(=O)=O)=C(C=C1)S([O-])(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Suramin hexasodium salt

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 50 35
DMSO 5 4

制备储备液 for Suramin hexasodium salt

以下数据基于产品分子量 1429.15。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.35 mM 2 mL 10 mL 19.99 mL
1.75 mM 0.4 mL 2 mL 4 mL
3.5 mM 0.2 mL 1 mL 2 mL
17.5 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for Suramin hexasodium salt

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Suramin hexasodium salt

参考文献是支持产品生物活性的出版物。

Beindl et al (1996) Inhibition of receptor/G protein coupling by suramin analogues. Mol.Pharmacol. 50 415 PMID: 8700151

Charlton et al (1996) PPADS and suramin as antagonists at cloned P2Y- and P2U-purinoceptors. Br.J.Pharmacol. 118 704 PMID: 8762097

Klinger et al (2001) Suramin and the suramin analogue NF307 discriminate among calmodulin-binding sites. Biochem.J. 355 827 PMID: 11311147

Voogd et al (1993) Recent research on the biological activity of suramin. Pharmacol.Rev. 45 177 PMID: 8396782

Hill et al (2004) Functional regulation of the cardiac ryanodine receptor by suramin and calmodulin involves multiple binding sites. Mol.Pharmacol. 65 1258 PMID: 15102954

Luo et al (2018) Suramin is a novel competitive antagonist selective to α1β2γ2 GABAA over ρ1 GABAC receptors. Neuropharmacology. 141 148 PMID: 30172846

If you know of a relevant reference for Suramin hexasodium salt, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Purinergic (P2X) Receptor Antagonists

关键词: Suramin hexasodium salt, Suramin hexasodium salt supplier, Non-Selective, P2, antagonists, P2X, P2Y, Uncouples, G, proteins, from, receptors, heterotrimeric, purinoceptors, ryanodine, ion, channels, GABAA, antagonism, Receptors, Heterotrimeric, G-protein, GTPases, Purinergic, Ryanodine, 1472, Tocris Bioscience

24 篇 Suramin hexasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Suramin hexasodium salt 的部分引用包括：

Naviaux et al (2015) Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model. Mol Autism 6 1 PMID: 25705365

Fonseca et al (2015) Diadenosine tetraphosphate contributes to CB-induced tear secretion. Purinergic Signal 11 87 PMID: 25398705

Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016 PMID: 25698739

Thrane et al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc Natl Acad Sci U S A 108 846 PMID: 21187412

Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126

Conley (2017) Imaging extracellular ATP with a genetically-encoded, ratiometric fluorescent sensor. PLoS One 12 e0187481 PMID: 29121644

Naviaux et al (2013) Antipurinergic therapy corrects the autism-like features in the poly(IC) mouse model. PLoS One 8 e57380 PMID: 23516405

Zierhut (2017) Role of purinergic signaling in experimental pneumococcal meningitis. Sci Rep 7 44625 PMID: 28300164

Nishimura et al (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog 11 e1005184 PMID: 26430888

Makris et al (2015) Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage. Tissue Eng Part A 21 884 PMID: 25473799

Sivaramakrishnan et al (2012) Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes. J Cell Sci 125 4567 PMID: 22767503

Yuryev et al (2016) In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex. Front Cell Neurosci 9 500 PMID: 26778965

Rosa et al (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. J Mol Neurosci 4 PMID: 26274565

Ibáñez et al (2012) A high throughput scintillation proximity imaging assay for protein methyltransferases. Comb Chem High Throughput Screen 15 359 PMID: 22256970

Hazleton et al (2012) Purinergic receptors are required for HIV-1 infection of primary human macrophages. J Immunol 188 4488 PMID: 22450808

Manohar et al (2012) ATP release and autocrine signaling through P2X4 receptors regulate γδ T cell activation. J Leukoc Biol 92 787 PMID: 22753954

Ledderose et al (2016) Mitochondrial Dysfunction, Depleted Purinergic Signaling, and Defective T Cell Vigilance and Immune Defense. J Infect Dis 213 456 PMID: 26150546

Zhang et al (2016) Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells. Sci Rep 6 28938 PMID: 27357477

Rodríguez-Zayas et al (2012) Blockade of P2 nucleotide receptors after spinal cord injury reduced the gliotic response and spared tissue. Am J Physiol Heart Circ Physiol 46 167 PMID: 21647706

Mikolajewicz et al (2018) Mechanically stimulated ATP release from murine bone cells is regulated by a balance of injury and repair. Elife 7 PMID: 30324907

Naviaux et al (2014) Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy. Transl Psychiatry 4 e400 PMID: 24937094

Malmersjö et al (2013) Neural progenitors organize in small-world networks to promote cell proliferation. J Pharmacol Exp Ther 110 E1524 PMID: 23576737

Verma et al (2005) Modulation of agonist binding to human DA receptor subtypes by L-prolyl-L-leucyl-glycinamide and a peptidomimetic analog. Elife 315 1228 PMID: 16126839

Price et al (2004) Cannabinoid receptor-independent actions of the aminoalkylindole WIN 55,212-2 on trigeminal sensory neurons. Br J Pharmacol 142 257 PMID: 15155534

您是否知道使用了 Tocris Suramin hexasodium salt 的优秀论文？ 请告知我们.

Suramin hexasodium salt 的评论

平均评分: 4.3 (基于 3 条评论。)

5 星
33%
4 星
67%
3 星
0%
2 星
0%
1 星
0%

Have you used Suramin hexasodium salt?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


good product, satisfied.
By Anonymous on 06/10/2019
分析类型： In Vitro
种属： Human
细胞系/组织： HuCCt1

The ATP induced expression of p-LKB1 was inhibited by Suramin in Cancer Cells.

review image
P2 receptor antagonist.
By Karthik krishnamurthy on 11/08/2018
分析类型： In Vitro
种属： Rat
细胞系/组织： co-culture of neurons and astrocytes

used to study synchronized calcium oscillations in co-cultures of neurons and glial cells

50 micromolar of suramin was bath applied

Non-selective P2X antagonist.
By Louis-Philippe Bernier on 05/17/2018
分析类型： Ex Vivo
种属： Mouse

Non-specific P2X blocker, worked as expected.

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.