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说明： p38 MAPK inhibitor
化学名： 6-Chloro-5-[[4-[(4-fluorophenyl)methyl]-1-piperidinyl]carbonyl-N,N,1-trimethyl-α-oxo-1H-indole-3-acetamide
纯度： ≥98% (HPLC)
生物活性 for SX 011
Potent p38α inhibitor (IC50 = 9 nM). Also inhibits p38β and JNK-2 (IC50 values are 90 nM and 100 nM respectively). Displays no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
技术数据 for SX 011
| 分子量 | 483.96 |
| 公式 | C26H27ClFN3O3 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 309913-42-6 |
| PubChem ID | 9935015 |
| InChI Key | GUTYHDCSDBBMGW-UHFFFAOYSA-N |
| Smiles | O=C(C(N(C)C)=O)C2=CN(C)C1=CC(Cl)=C(C(N3CCC(CC4=CC=C(F)C=C4)CC3)=O)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for SX 011
参考文献 for SX 011
参考文献是支持产品生物活性的出版物。
Lee and Dominguez (2005) MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein. Curr.Med.Chem. 12 2979 PMID: 16378500
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关键词: SX 011, SX 011 supplier, SX011, p38, inhibitors, inhibits, MAPK, p38alpha, p38beta, p38a, p38b, signaling, signalling, Mitogen-Activated, Protein, Kinases, 3639, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for SX 011
