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T 112

Cat. No. 7690 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Estrogen-related receptor γ agonist; promotes maturation of hiPSC-derived cardiomyocytes
化学名： 2-[2-(4-Bromophenyl)-1H-benzimidazol-6-yl]-2,3-dihydro-5-(4-morpholinyl)-1H-isoindol-1-one
纯度： ≥98% (HPLC)
说明书
引用文献
评论
通路 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for T 112

T 112 is an estrogen-related receptor gamma (ERRγ) agonist. Promotes maturation of hiPSC-derived cardiomyocytes. T 112 accelerates metabolic and sarcomere maturation in cardiomyocytes, as well as maturation of contractile and electrophysiological properties and ultrastructure organization, when used alone or in combination with other small molecules.

许可信息

Sold under license from Orizuru Therapeutics

技术数据 for T 112

分子量 489.37
公式 C25H21BrN4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2376876-87-6
PubChem ID 151597503
InChI Key QJTVIYLRDQROJD-UHFFFAOYSA-N
Smiles BrC1=CC=C(C2=NC3=CC=C(N4CC5=CC(N6CCOCC6)=CC=C5C4=O)C=C3N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for T 112

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 4.89 10

制备储备液 for T 112

以下数据基于产品分子量 489.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.1 mM 20.43 mL 102.17 mL 204.34 mL
0.5 mM 4.09 mL 20.43 mL 40.87 mL
1 mM 2.04 mL 10.22 mL 20.43 mL
5 mM 0.41 mL 2.04 mL 4.09 mL

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参考文献 for T 112

参考文献是支持产品生物活性的出版物。

Miki et al (2021) ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes. Nat.Commun. 12 3596 PMID: 34155205

If you know of a relevant reference for T 112, please let us know.

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关键词: T 112, T 112 supplier, T112, hiPSC, human, induced, pluripotent, stem, cells, cardiomyocyte, differentiation, maturation, estrogen, receptor, gamma, agonists, agonism, ERRgamma, γ, Estrogen, and, Related, Receptors, Cardiomyocyte, Stem, Cells, 7690, Tocris Bioscience

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Pathways for T 112

Estrogen Signaling Pathway

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.