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t-TUCB

Cat. No. 6757 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent soluble epoxide hydrolase (sEH) Inhibitor; anti-inflammatory and antinociceptive
化学名： 4-[[trans-4-[[[[4-(Trifluoromethoxy)phenyl]amino]carbonyl]amino]cyclohexyl]oxy]benzoic acid
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for t-TUCB

t-TUCB is a potent soluble epoxide hydrolase (sEH) Inhibitor (IC50 = 0.9 nM). Enhances hepatic eNOS phosphorylation and NO release. Exhibits antihypertensive and cardioprotective actions in cirrhotic rat models. Suppress the activation of HSCs and reduce hepatic fibrosis through inhibition of NF-κB/IκBα signaling. Anti-inflammatory and antinociceptive.

技术数据 for t-TUCB

分子量 438.4
公式 C21H21F3N2O5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 948304-40-3
PubChem ID 16756850
InChI Key XDVFKCZZXOGEMN-UHFFFAOYSA-N
Smiles OC(C1=CC=C(C=C1)O[C@H]2CC[C@H](NC(NC3=CC=C(C=C3)OC(F)(F)F)=O)CC2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for t-TUCB

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.84 100

制备储备液 for t-TUCB

以下数据基于产品分子量 438.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.41 mL 22.81 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Molarity Calculator

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Reconstitution Calculator

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参考文献 for t-TUCB

参考文献是支持产品生物活性的出版物。

Hwang et al (2007) Orally bioavailable potent soluble epoxide hydrolase inhibitors. J.Med.Chem. 50 3825 PMID: 17616115

Deng et al (2017) Inhibition of soluble epoxide hydrolase lowers portal hypertension in cirrhotic rats by ameliorating endothelial dysfunction and liver fibrosis. Prostaglandins Other Lipid Mediat. 131 67 PMID: 28822809

If you know of a relevant reference for t-TUCB, please let us know.

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关键词: t-TUCB, t-TUCB supplier, potent, soluble, epoxide, hydrolase, inhibitors, inhibits, sEH, anti-inflammatory, cardioprotective, Other, Hydrolases, 6757, Tocris Bioscience

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