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Cat. No. 8825 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： TERT activator

化学名： N-(3-Chloro-4-fluorophenyl)-4-fluoro-3,5-dimethylbenzenesulfonamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TAC

TAC is a telomerase reverse transcriptase (TERT) activator. TAC upregulates TERT gene transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC enhances telomere synthesis, reduces tissue aging markers, cellular senescence, and inflammatory cytokines. In the brain, TAC induces neurogenesis, reduces neuroinflammation, and preserves cognitive function.

技术数据 for TAC

分子量	331.76
公式	C₁₄H₁₂ClF₂NO₂S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	666699-46-3
PubChem ID	2805068
InChI Key	JVUSVLUQMXGABO-UHFFFAOYSA-N
Smiles	O=S(NC1=CC=C(C(Cl)=C1)F)(C2=CC(C)=C(F)C(C)=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TAC

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	33.18	100
	ethanol	33.18	100

制备储备液 for TAC

以下数据基于产品分子量 331.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.01 mL	15.07 mL	30.14 mL
5 mM	0.6 mL	3.01 mL	6.03 mL
10 mM	0.3 mL	1.51 mL	3.01 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for TAC

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TAC

参考文献是支持产品生物活性的出版物。

Shim et al (2024) TERT activation targets DNA methylation and multiple aging hallmarks. Cell 187 4030 PMID: 38908367

If you know of a relevant reference for TAC, please let us know.

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关键词: TAC, TAC supplier, telomerase, reverse, transcriptase, transcription, activates, activators, aging, DNA, RNA, telomeres, Telomerase, DNA,, and, Protein, Synthesis, 8825, Tocris Bioscience

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