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说明： GABAA agonist; also GABA-T substrate and GABA uptake inhibitor
化学名： trans-4-Aminocrotonic acid
生物活性 for TACA
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
技术数据 for TACA
| 分子量 | 101.1 |
| 公式 | C4H7NO2 |
| 储存 | Store at RT |
| CAS Number | 38090-53-8 |
| PubChem ID | 5310987 |
| InChI Key | FMKJUUQOYOHLTF-OWOJBTEDSA-N |
| Smiles | NC/C=C/C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TACA
参考文献 for TACA
参考文献是支持产品生物活性的出版物。
Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551 PMID: 9422798
Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157 PMID: 234147
Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319 PMID: 8885697
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关键词: TACA, TACA supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, GABAA-rho, 0181, Tocris Bioscience
1 篇 TACA 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TACA 的部分引用包括：
Jensen (2013) Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa. PLoS One 8 e79126 PMID: 24205371
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.