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说明： Non-selective, endogenous glycine receptor partial agonist
化学名： 2-Aminoethylsulfonic acid
生物活性 for Taurine
One of the most abundant free amino acids in the brain. A partial agonist at the inhibitory glycine receptor. May be used in protocols for the generation of retinal pigment epithelial cells from hPSCs. Taurine-fed middle-aged mice have improved functioning of bone, muscle, pancreas, brain, fat, gut, and immune system, and a longer life span. It reduces cellular senescence, protected against telomerase deficiency, suppressed mitochondrial dysfunction, decreased DNA damage, and attenuated inflammation. Taurine supplementation increases health span and life span in worms and health span in non-human primates.
技术数据 for Taurine
| 分子量 | 125.14 |
| 公式 | C2H7NO3S |
| 储存 | Store at RT |
| CAS Number | 107-35-7 |
| PubChem ID | 1123 |
| InChI Key | XOAAWQZATWQOTB-UHFFFAOYSA-N |
| Smiles | NCCS(=O)(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Taurine
参考文献 for Taurine
参考文献是支持产品生物活性的出版物。
Boldyrev et al (1999) Carnosine and taurine protect rat cerebellar granular cells from free radical damage. Neurosci.Lett. 263 169 PMID: 10213162
Chung et al (1996) Saturable disposition of taurine in the rat cerebrospinal fluid. J.Pharmacol.Exp.Ther. 276 676 PMID: 8632336
Palmi et al (1999) Potentiation of mitochondrial Ca2+ sequestration by taurine. Biochem.Pharmacol. 58 1123 PMID: 10484070
Schmieden and Betz (1995) Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol.Pharmacol. 48 919 PMID: 7476923
Surendran et al (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc. 3 101803 PMID: 36386870
Singh et al (2023) Taurine deficiency as a driver of aging. Science 380 eabn9257 PMID: 37289866
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关键词: Taurine, Taurine supplier, Non-Selective, endogenous, glycine, receptor, partial, agonists, GlyR, Glycine, Receptors, inhibitory, amino, acid, RPE, retinal, pigment, epithelial, differentiation, Organoids, Retinal, Stem, Cells, 0209, Tocris Bioscience
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