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说明： Selective PP1 inhibitor
化学名： (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-16-Ethyl-3,7-dihydroxy-1,2,6,10,12-pentamethyl-5,14-dioxo-15,17-octadecadienyl 2,5-dihydro-β-hydroxy-4-methyl-2,5-dioxo-3-furanpropanoic acid ester
纯度： ≥95% (HPLC)
生物活性 for Tautomycetin
Tautomycetin is a selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells.
技术数据 for Tautomycetin
| 分子量 | 606.75 |
| 公式 | C33H50O10 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 119757-73-2 |
| PubChem ID | 16759609 |
| InChI Key | VAIBGAONSFVVKI-CIFLJJJCSA-N |
| Smiles | O=C(O1)C([C@H](O)CC(O[C@H](C)[C@@H](C)[C@H](O)CC([C@@H](C)[C@@H](O)CC[C@H](C)C[C@@H](C)CC(/C=C(CC)/C=C)=O)=O)=O)=C(C)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tautomycetin
参考文献 for Tautomycetin
参考文献是支持产品生物活性的出版物。
Mitsuhashi et al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328 PMID: 11554729
Shim et al (2002) Immunosuppressive effects of tautomycetin in vivo and in vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617 PMID: 12149481
Kim et al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959 PMID: 15919517
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关键词: Tautomycetin, Tautomycetin supplier, Selective, PP1, inhibitors, inhibits, Calcineurin, Protein, Ser/Thr, Phosphatases, immunosuppressants, transplant, PP2, TC, Immunosuppressants, 2305, Tocris Bioscience
17 篇 Tautomycetin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tautomycetin 的部分引用包括：
Engmann et al (2015) DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. Nat Commun 6 10099 PMID: 26639316
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. PLoS Genet 7 62 PMID: 25071439
Hégarat et al (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. Anticancer Res 10 e1004004 PMID: 24391510
Walsh and Young (2011) TGF-β regulation of focal adhesion proteins and motility of premalignant oral lesions via protein phosphatase 1. Anticancer Res 31 3159 PMID: 21965722
Georgilis et al (2018) PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells. Cancer Cell 34 85 PMID: 29990503
Wan et al (2018) M-Calpain Activation Facilitates Seizure Induced KCC2 Down Regulation. Front Mol Neurosci 11 287 PMID: 30186110
Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Front Neurosci 33 15879 PMID: 24089494
Toledo et al (2013) A novel effect of MARCKS phosphorylation by activated PKC: the dephosphorylation of its serine 25 in chick neuroblasts. PLoS One 8 e62863 PMID: 23634231
Walsh and Young (2010) Interrelationship between protein phosphatase 1 and TGF-{β} in regulating motility and cytoskeletal architecture of endothelial cells. J Neurosci 30 4861 PMID: 21187463
Messal et al (2019) Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature 566 126 PMID: 30700911
Huang et al (2014) PP1γ functionally augments the alternative splicing of CaMKIIδ through interaction with ASF. Am J Physiol Cell Physiol 306 C167 PMID: 24196533
Isensee et al (2014) Pain modulators regulate the dynamics of PKA-RII phosphorylation in subgroups of sensory neurons. J Cell Sci 127 216 PMID: 24190886
Pyo et al (2018) ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep 25 2878 PMID: 30517873
Liu (2018) In vivo brain GPCR signaling elucidated by phosphoproteomics. Science 360 eaao4927 PMID: 29930108
Hiraga et al (2017) Human RIF1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation. EMBO Rep 18 403 PMID: 28077461
Garzón et al (2019) Human RIF1-Protein Phosphatase 1 Prevents Degradation and Breakage of Nascent DNA on Replication Stalling. Cell Rep 27 2558 PMID: 31141682
Alver et al (2017) Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. Cell Rep 18 2508 PMID: 28273463
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