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说明： Receptor-selective retinoid; binds RAR-β and -γ
化学名： 6-[2-(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
纯度： ≥99% (HPLC)
生物活性 for Tazarotene
Receptor-selective acetylenic retinoid; binds at retinoid acid receptors (RAR) -β and -γ. Topically used for the treatment of skin disorders, particularly psoriasis and acne. Implicated in the treatment of basal cell carcinomas; induces upregulation of Bax in vivo. Exhibits antiproliferative and proapoptotic activity. Upregulates TIGs (Tazarotene-induced genes), including the cell adhesion molecule TIG1 and the tumor-suppressor TIG3.
技术数据 for Tazarotene
| 分子量 | 351.46 |
| 公式 | C21H21NO2S |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 118292-40-3 |
| PubChem ID | 5381 |
| InChI Key | OGQICQVSFDPSEI-UHFFFAOYSA-N |
| Smiles | CC1(C)C2=C(C=CC(C#CC3=NC=C(C(OCC)=O)C=C3)=C2)SCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Tazarotene
参考文献 for Tazarotene
参考文献是支持产品生物活性的出版物。
Higuchi et al (2003) Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lungcarcinoma cells and its association with suppression of the transformed phenotype. Oncogene 22 4627 PMID: 12879006
Orlandi et al (2004) Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazar. J.Invest.Dermatol. 122 1037 PMID: 15102095
Son et al (2009) Expression and mutation analysis of TIG1 (Tazarotene-induced gene 1) in human gastric cancer. Oncol.Res. 17 571 PMID: 19806788
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关键词: Tazarotene, Tazarotene supplier, receptor-selective, retinoid, RARbeta, RARgamma, retinoic, acid, receptor, treats, skin, conditions, Retinoic, Acid, Receptors, 3997, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.