Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTB 21007
说明： α5-selective GABAA inverse agonist
化学名： 6,7-Dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-benzo[c]thiophen-4(5H)-one
纯度： ≥99% (HPLC)
生物活性 for TB 21007
TB 21007 is a GABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
技术数据 for TB 21007
| 分子量 | 339.5 |
| 公式 | C15H17NO2S3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 207306-50-1 |
| PubChem ID | 6918633 |
| InChI Key | QILRYFCEXLFIDS-UHFFFAOYSA-N |
| Smiles | O=C2C1=C(SCCO)SC(C3=NC=CS3)=C1CC(C)(C)C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TB 21007
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 33.95 | 100 | |
| ethanol | 8.49 | 25 |
制备储备液 for TB 21007
以下数据基于产品分子量 339.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.95 mL | 14.73 mL | 29.46 mL |
| 5 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 10 mM | 0.29 mL | 1.47 mL | 2.95 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.59 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for TB 21007
参考文献 for TB 21007
参考文献是支持产品生物活性的出版物。
Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227 PMID: 12747794
If you know of a relevant reference for TB 21007, please let us know.
按产品操作查看相关产品
关键词: TB 21007, TB 21007 supplier, α5, alpha5-selective, GABAA, inverse, agonists, Receptors, TB21007, 2905, Tocris Bioscience
2 篇 TB 21007 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TB 21007 的部分引用包括：
De la Luz-Cuellar et al (2019) Blockade of spinal α5-GABAA receptors differentially reduces reserpine-induced fibromyalgia-type pain in female rats. Eur J Pharmacol 858 172443 PMID: 31181208
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Clin Invest 64 145 PMID: 22732440
您是否知道使用了 Tocris TB 21007 的优秀论文？ 请告知我们.
TB 21007 的评论
目前没有该产品的评论。 Be the first to review TB 21007 and earn rewards!
Have you used TB 21007?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.