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说明： CXCR4 antagonist; ACKR3 (CXCR7) agonist
纯度： ≥95% (HPLC)
生物活性 for TC 14012
TC 14012 is a CXCR4 antagonist and ACKR3 (CXCR7) agonist (EC50 = 350 nM for CXCR7).
技术数据 for TC 14012
| 分子量 | 2066.43 |
| 公式 | C90H140N34O19S2 |
| 序列 |
RRACYXKXPYRXCR (Modifications: Disulfide bridge: 4-13, Ala-3 = 3-(2-naphthalenyllalanine), X-6 and X-12 = L-Citrulline, X-8 = D-Citrulline, Arg-14 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 368874-34-4 |
| PubChem ID | 90488928 |
| InChI Key | SGDDHDBBOJNZKY-UXNLHULBSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC2=CC=CC=C2C=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=O)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TC 14012
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for TC 14012
参考文献 for TC 14012
参考文献是支持产品生物活性的出版物。
Tamamura et al (2003) Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org.Biomol.Chem. 1 3656 PMID: 14649896
Burger et al (2005) Small peptide inhibitors of the CXCR4 chemokine receptor (CS184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106 1824 PMID: 15905192
Gravel et al (2010) The peptidomimetic CXCR4 antagonist TC14012 recruits beta arrestin to CXCR7: roles of receptor domains. J.Biol.Chem. 285 37939 PMID: 20956518
If you know of a relevant reference for TC 14012, please let us know.
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关键词: TC 14012, TC 14012 supplier, TC14012, cxcr4, antagonists, inverse, agonists, cxcr7, chemokines, Chemokine, CXC, Receptors, 4300, Tocris Bioscience
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