TC 2559 difumarate

Cat. No. 2737 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Selective α4β2 nAChR partial agonist

化学名： 4-(5-ethoxy-3-pyridinyl)-N-methyl-(3E)-3-buten-1-amine difumarate

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC 2559 difumarate

TC 2559 difumarate is a subtype-selective partial agonist for α4β2 nicotinic acetylcholine receptors (EC₅₀ values are 0.18, 12.5, 14.0, > 30, > 100 and > 100 μM for α4β2, α4β4, α2β4, α3β4, α3β2 and α7 receptor subtypes respectively). Displays selectivity for (α4)₂(β2)₃ receptor stoichiometry and enhanced CNS-PNS selectivity ratio. Attenuates scopolamine-induced cognitive deficits in a step-through passive avoidance task.

技术数据 for TC 2559 difumarate

分子量	438.43
公式	C₁₂H₁₈N₂O.2C₄H₄O₄
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	2454492-41-0
PubChem ID	56972184
InChI Key	GEWVPSJQGJBDLM-MYBAKCFCSA-N
Smiles	CCOC1=CN=CC(/C=C/CCNC)=C1.O=C(O)/C=C/C(O)=O.O=C(O)/C=C/C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC 2559 difumarate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	43.84	100

制备储备液 for TC 2559 difumarate

以下数据基于产品分子量 438.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.4 mL	22.81 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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产品说明书 for TC 2559 difumarate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC 2559 difumarate

参考文献是支持产品生物活性的出版物。

Bencherif et al (2000) TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors. Eur.J.Pharmacol. 409 45 PMID: 11099699

Chen et al (2003) The nicotinic α4β2 receptor selective agonist, TC-2559, increases DA neuronal activity in the ventral tegmental area of rat midbrain slices. Neuropharmacology 45 334 PMID: 12871651

Zwart et al (2006) 5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors. Eur.J.Pharmacol. 539 10 PMID: 16674940

If you know of a relevant reference for TC 2559 difumarate, please let us know.

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关键词: TC 2559 difumarate, TC 2559 difumarate supplier, Selective, partial, agonists, α4β2, alpha4beta2, receptors, Nicotinic, Receptors, Acetylcholine, nAChR, TC2559, difumarate, 212332-35-9, (a4b2), 2737, Tocris Bioscience

2 篇 TC 2559 difumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC 2559 difumarate 的部分引用包括：

Kiguchi (2018) Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury. J Neuroinflammation 15 96 PMID: 29587798

Sun et al (2009) Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther 8 110 PMID: 19139119

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