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说明： Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs
化学名： 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
纯度： ≥98% (HPLC)
生物活性 for Thalidomide-4-hydroxyacetate
Thalidomide-4-hydroxyacetate is a derivative of Thalidomide (Cat.No. 0652), commonly used as a precursor to PROTAC® that hijacks cereblon as the E3 ubiquitin ligase component. Supplied with a carboxylic acid functional handle at a position known not to significantly affect binding to cereblon, for ready conjugation to a linker/target protein ligand.
Thalidomide-4-hydroxyacetate has been recently renamed. The previous name for this product was TC E3 5031.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Require a different derivative? Get in touch.
Usage Guidelines for Thalidomide-4-hydroxyacetate
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for Thalidomide-4-hydroxyacetate
| 分子量 | 332.26 |
| 公式 | C15H12N2O7 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1061605-21-7 |
| PubChem ID | 25015436 |
| InChI Key | ZVWIXIGBWIEDFO-UHFFFAOYSA-N |
| Smiles | O=C(N1C(CC2)C(NC2=O)=O)C3=C(C1=O)C(OCC(O)=O)=CC=C3 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Thalidomide-4-hydroxyacetate
参考文献 for Thalidomide-4-hydroxyacetate
参考文献是支持产品生物活性的出版物。
Lohbeck and Miller (2016) Practical synthesis of a phthalimide-based cereblon ligand to enable PROTAC development. Bioorg.Med.Chem.Lett. 26 5260 PMID: 27687673
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关键词: Thalidomide-4-hydroxyacetate, Thalidomide-4-hydroxyacetate supplier, PROTACs, thalidomide, PROteolysis, TArgeting, Chimeras, cereblon, E3, ligase, ligand, 3, TCE35031, 2434840-81-8, 2357105-38-3, Functionalized, Ligase, Ligands, 6466, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia