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TC E3 5032

Cat. No. 6628 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6628 has been discontinued.

View all Functionalized E3 Ligase Ligands products.
说明： Precursor to Pomalidomide-based PROTACs
化学名： 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for TC E3 5032

TC E3 5032 is a functionalized cereblon ligand for PROTAC® research and development. Precursor to Pomalidomide (Cat.No. 6302) -based PROTACs. Incorporates a fluoro leaving group to allow conjugation to amine linker. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for TC E3 5032

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for TC E3 5032

分子量 276.22
公式 C13H9FN2O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 835616-60-9
PubChem ID 11859051
InChI Key CRAUTELYXAAAPW-UHFFFAOYSA-N
Smiles O=C(C1=C(C=CC=C1C2=O)F)N2C3CCC(NC3=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for TC E3 5032

参考文献是支持产品生物活性的出版物。

Remillard et al (2017) Degradation of the BAF complex factor BRD9 by heterobifunctional ligands. Angew.Chem.Int.Ed.Engl. 56 5738 PMID: 28418626

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关键词: TC E3 5032, TC E3 5032 supplier, TCE35032, Proteolysis, Targeting, Chimera, PROTAC, cereblon, E3, ubiquitin, ligase, CRBN, 911109-85-8, 2243823-26-7, Functionalized, Ligase, Ligands, 6628, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia