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Submit ReviewTC-H 106
说明： Class I histone deacetylase inhibitor
化学名： N1-(2-Aminophenyl)-N7-(4-methylphenyl)heptanediamide
纯度： ≥99% (HPLC)
生物活性 for TC-H 106
TC-H 106 is a class I histone deacetylase (HDAC) inhibitor (IC50 values are 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively). Exhibits slow, tight-binding inhibitory activity. Displays no activity against class II HDACs. Brain penetrant.
技术数据 for TC-H 106
| 分子量 | 339.43 |
| 公式 | C20H25N3O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 937039-45-7 |
| PubChem ID | 16070100 |
| InChI Key | WTKBRPXPNAKVEQ-UHFFFAOYSA-N |
| Smiles | NC1=CC=CC=C1NC(CCCCCC(NC2=CC=C(C)C=C2)=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TC-H 106
参考文献 for TC-H 106
参考文献是支持产品生物活性的出版物。
Chou et al (2008) Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases. J.Biol.Chem. 283 35402 PMID: 18953021
Rai et al (2008) HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PLoS ONE 3 e1958 PMID: 18463734
Xu et al (2009) Chemical probes identify a role for histone deacetylase 3 in Friedrich's ataxia gene silencing. Chem.Biol. 16 980 PMID: 19778726
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关键词: TC-H 106, TC-H 106 supplier, TC-H106, histones, deacetylases, hdacs, inhibitiors, class, I, HDAC3, HDAC1, epigenetics, Class, HDACs, 4270, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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