TC-I 15

Cat. No. 4527 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent α₂β₁ inhibitor; displays antithrombotic activity in vivo

化学名： N-[[(4R)-5,5-Dimethyl-3-(phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[(phenylmethyl)amino]carbonyl]amino]-L-alanine

纯度： ≥98% (HPLC)

引用文献 (4)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for TC-I 15

TC-I 15 is a potent α₂β₁ integrin inhibitor (IC₅₀ values for the inhibition of human platelet adhesion to type I collagen are 12 and 715 nM for platelets under static conditions and under flow, respectively). TC-I 15 displays selectivity for α₂β₁ over α_vβ₃, α₅β₁, α₆β₁ and α_IIbβ₃ at concentrations exceeding 1000 nM. TC-I 15 reduces collagen IV production in mesangial cells. Active in vivo; TC-I 15 prevents ferric chloride-induced clot formation in mice.

许可信息

Sold under license from the University of Pennsylvania.

技术数据 for TC-I 15

分子量	520.62
公式	C₂₃H₂₈N₄O₆S₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	916734-43-5
PubChem ID	90488948
InChI Key	XKLHCUGVLCGKKX-RBUKOAKNSA-N
Smiles	CC1(C)SCN(S(C3=CC=CC=C3)(=O)=O)[C@@H]1[C@@](N[C@H](C(O)=O)CNC(NCC2=CC=CC=C2)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TC-I 15

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	52.06	100

制备储备液 for TC-I 15

以下数据基于产品分子量 520.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.92 mL	9.6 mL	19.21 mL
5 mM	0.38 mL	1.92 mL	3.84 mL
10 mM	0.19 mL	0.96 mL	1.92 mL
50 mM	0.04 mL	0.19 mL	0.38 mL

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产品说明书 for TC-I 15

分析证书/产品说明书

化学品安全技术说明书

参考文献 for TC-I 15

参考文献是支持产品生物活性的出版物。

Borza et al (2012) Inhibition of integrin α2β1 ameliorates glomerular injury. J.Am.Soc.Nephrol. 23 1027 PMID: 22440900

Miller et al (2009) Small-molecule inhibitors of integrin α2β1 that prevent pathological thrombus formation via an allosteric mechanism. Proc.Natl.Acad.Sci.U.S.A. 106 719 PMID: 19141632

If you know of a relevant reference for TC-I 15, please let us know.

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关键词: TC-I 15, TC-I 15 supplier, TC-I15, integrins, receptors, a2b1, alpha2beta1, α2β1, inhibitors, inhibits, potent, selective, active, in, vivo, antithrombotics, collagen, Integrins, Cell, Adhesion, Molecules, 4527, Tocris Bioscience

4 篇 TC-I 15 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TC-I 15 的部分引用包括：

Li et al (2018) Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responses. Nat Commun 9 3600 PMID: 30190514

Hunter et al (2021) Selectivity of the collagen-binding integrin inhibitors, TC-I-15 and obtustatin. Toxicol.Appl.Pharmacol. 428 115669 PMID: 34363821

Baghdadi (2018) Reciprocal signalling by Notch-Collagen V-CALCR retains muscle stem cells in their niche. Nature 557 714 PMID: 29795344

Viola et al (2020) Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis. Elife 9 PMID: 33026975

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.