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Discontinued Product
1225 has been discontinued.
View all Constitutive Androstane Receptor products.
说明： Constitutive androstane receptor agonist
化学名： 1,4-Bis(3,5-Dichloro-2-pyridinyloxy)benzene
纯度： ≥98% (HPLC)
生物活性 for TCPOBOP
TCPOBOP is an agonist of the constitutive androstane receptor (CAR) (EC50 = 20 nM). Induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Potent mitogen; induces liver cell proliferation in mice.
技术数据 for TCPOBOP
| 分子量 | 402.06 |
| 公式 | C16H8Cl4N2O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 76150-91-9 |
| PubChem ID | 5382 |
| InChI Key | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| Smiles | ClC(C=N3)=CC(Cl)=C3OC(C=C2)=CC=C2OC1=NC=C(Cl)C=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCPOBOP
参考文献 for TCPOBOP
参考文献是支持产品生物活性的出版物。
Ledda-Columbano et al (1998) In vivo hepatocyte proliferation is inducible through a TNF and IL-6-independent pathway. Oncogene 17 1039 PMID: 9747883
Poland et al (1980) 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, a potent phenobarbital-like inducer of microsomal monooxygenase activity. Mol.Pharmacol. 18 571 PMID: 7464820
Tzameli et al (2000) The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. Mol.Cell.Biol. 20 2951 PMID: 10757780
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关键词: TCPOBOP, TCPOBOP supplier, agonists, nuclear, receptor, CAR, constitutive, androstane, receptors, mitogens, mitogenic, Constitutive, Androstane, Receptor, 1225, Tocris Bioscience
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