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Submit ReviewTCS 1105
说明： GABAA α2 benzodiazepine agonist
化学名： N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide
纯度： ≥99% (HPLC)
生物活性 for TCS 1105
GABAA benzodiazepine receptor (BZR) ligand. Acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki values are 118 and 245 nM respectively). Anxiolytic agent lacking sedative activity.
技术数据 for TCS 1105
| 分子量 | 296.3 |
| 公式 | C17H13FN2O2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 185391-33-7 |
| PubChem ID | 2986030 |
| InChI Key | VWCCHJFFYCGXFL-UHFFFAOYSA-N |
| Smiles | O=C(C(NCC3=CC=C(F)C=C3)=O)C2=CNC1=CC=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 1105
参考文献 for TCS 1105
参考文献是支持产品生物活性的出版物。
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) α2 benzodiazepine receptor. J.Med.Chem 52 3723 PMID: 19469479
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关键词: TCS 1105, TCS 1105 supplier, TCS1105, alpha2, agonist, alpha1, antagonist, GABA, a1, a2, α2, α1, GABAA, benzodiazepine, receptor, BZR, Receptors, 3942, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.