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Submit ReviewTCS 1205
说明： GABAA agonist; displays subtype selectivity
化学名： 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
纯度： ≥99% (HPLC)
生物活性 for TCS 1205
GABAA α2 agonist and GABAA α1 partial agonist in vitro (Ki values are 14 and 121 nM respectively). Exhibits non-sedative anxiolytic activity in vivo.
技术数据 for TCS 1205
| 分子量 | 337.33 |
| 公式 | C18H15N3O4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 355022-97-8 |
| PubChem ID | 10315001 |
| InChI Key | VCKKJKQZHHPPDR-LLVKDONJSA-N |
| Smiles | O=C(C(N[C@H](C)C3=CC=CC=C3)=O)C2=CNC1=CC=C([N+]([O-])=O)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 1205
参考文献 for TCS 1205
参考文献是支持产品生物活性的出版物。
Primofiore et al (2001) Novel N-(arylalkyl)indol-3-ylglyoxylamides targeted as ligands of the benzodiazepine receptor: synthesis, biological evaluation, and molecular modeling analysis of the structure-activity relationships. J.Med.Chem. 44 2286 PMID: 11428922
Taliani et al (2009) Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the γ-aminobutyric acid-A (GABAA) κ2 benzodiazepine receptor. J.Med.Chem. 52 3723 PMID: 19469479
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关键词: TCS 1205, TCS 1205 supplier, TCS1205, GABAA, receptors, subtype-selective, Receptors, 3941, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.