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Submit ReviewTCS 401
说明： Selective inhibitor of PTP1B
化学名： 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride
纯度： ≥98% (HPLC)
生物活性 for TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
技术数据 for TCS 401
| 分子量 | 306.72 |
| 公式 | C10H10N2O5S.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 243966-09-8 |
| PubChem ID | 56972185 |
| InChI Key | LQGCAMWQDSYOAY-UHFFFAOYSA-N |
| Smiles | O=C(C(O)=O)NC2=C(C(O)=O)C1=C(S2)CNCC1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for TCS 401
参考文献 for TCS 401
参考文献是支持产品生物活性的出版物。
Iversen et al (2000) Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem. 275 10300 PMID: 10744717
Andersen et al (2002) Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B. J.Med.Chem. 45 4443 PMID: 12238924
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关键词: TCS 401, TCS 401 supplier, Selective, inhibitors, inhibits, PTP1B, Shp1, Shp2, Protein, Tyrosine, Phosphatases, TCS401, 2754, Tocris Bioscience
1 篇 TCS 401 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS 401 的部分引用包括：
Du et al (2015) Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. J Neurosci 21 523 PMID: 25999679
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