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Submit ReviewTCS JNK 6o
说明： Selective JNK inhibitor
化学名： N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide
纯度： ≥98% (HPLC)
生物活性 for TCS JNK 6o
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC50 values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro.
TCS JNK 6o synthesized to Ancillary Material Grade also available.
技术数据 for TCS JNK 6o
| 分子量 | 356.38 |
| 公式 | C18H20N4O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 894804-07-0 |
| PubChem ID | 11624601 |
| InChI Key | KQMPRSZTUSSXND-UHFFFAOYSA-N |
| Smiles | CCOC1=NC(NC(=O)CC2=CC(OC)=CC=C2OC)=CC(N)=C1C#N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for TCS JNK 6o
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 35.64 | 100 |
制备储备液 for TCS JNK 6o
以下数据基于产品分子量 356.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.81 mL | 14.03 mL | 28.06 mL |
| 5 mM | 0.56 mL | 2.81 mL | 5.61 mL |
| 10 mM | 0.28 mL | 1.4 mL | 2.81 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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产品说明书 for TCS JNK 6o
参考文献 for TCS JNK 6o
参考文献是支持产品生物活性的出版物。
Szczepankiewicz et al (2006) Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 49 3563 PMID: 16759099
Kauskot et al (2007) Involvement of the mirogen-activated protein kinase c-Jun NH2-terminal kinase 1 in thrombus formation. J.Biol.Chem. 282 31990 PMID: 17785464
If you know of a relevant reference for TCS JNK 6o, please let us know.
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关键词: TCS JNK 6o, TCS JNK 6o supplier, TCSJNK6o, c-Jun, N-terminal, kinase, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, JNK/c-jun, 3222, Tocris Bioscience
3 篇 TCS JNK 6o 的引用文献
引用文献是使用了 Tocris 产品的出版物。 TCS JNK 6o 的部分引用包括：
Yang et al (2017) Establishment of mouse expanded potential stem cells. Nature 550 393 PMID: 29019987
Xiao et al (2019) Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discov 5 2 PMID: 30622738
Souvannaseng et al (2018) Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection. PLoS Pathog 14 e1007418 PMID: 30496310
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for TCS JNK 6o
