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说明： Functionalized cereblon ligand for PROTAC development
化学名： 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid
纯度： ≥95% (HPLC)
生物活性 for tDHU, acid
tDHU, acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a benzoic acid functional handle for ready conjugation to a linker/target protein ligand.
Part of a range of functionalized tool molecules for PROTAC® Degrader R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for tDHU, acid
This product is provided for use in onward chemistry. Suitable solvents can be used.
技术数据 for tDHU, acid
| 分子量 | 248.24 |
| 公式 | C12H12N2O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2377643-37-1 |
| PubChem ID | 139534352 |
| InChI Key | NXRZIUASGSMTJJ-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=C(C)C(N2C(NC(CC2)=O)=O)=C1)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for tDHU, acid
参考文献 for tDHU, acid
参考文献是支持产品生物活性的出版物。
Hendrick et al (2022) Direct-to-Biology accelerates PROTAC synthesis and the evaluation of linker effects on permeability and degradation. ACS.Med.Chem.Lett. 13 1182 PMID: 35859867
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关键词: tDHU, acid, tDHU, acid supplier, carboxylic, acid-functionalized, cereblon, ligand, tDHU, PROTAC, Degraders, building, blocks, targeted, protein, degradation, TPD, Functionalized, E3, Ligase, Ligands, 7773, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia