Telenzepine dihydrochloride

Cat. No. 1122 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective M₁ antagonist

化学名： 4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride

纯度： ≥98% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Telenzepine dihydrochloride

Telenzepine dihydrochloride is a selective high affinity muscarinic M₁ receptor antagonist (K_i = 0.94 nM). Inhibits gastric acid secretion.

技术数据 for Telenzepine dihydrochloride

分子量	443.39
公式	C₁₉H₂₂N₄O₂S.2HCl
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	147416-96-4
PubChem ID	6419995
InChI Key	JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles	Cl.Cl.CN1CCN(CC(=O)N2C3=C(C)SC=C3C(=O)NC3=C2C=CC=C3)CC1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Telenzepine dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	44.34	100

制备储备液 for Telenzepine dihydrochloride

以下数据基于产品分子量 443.39。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.26 mL	11.28 mL	22.55 mL
5 mM	0.45 mL	2.26 mL	4.51 mL
10 mM	0.23 mL	1.13 mL	2.26 mL
50 mM	0.05 mL	0.23 mL	0.45 mL

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产品说明书 for Telenzepine dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Telenzepine dihydrochloride

参考文献是支持产品生物活性的出版物。

Christofi et al (1991) Neuropharmacology of the muscarinic antagonist telenzepine in myenteric ganglia of the guinea-pig small intestine. Eur.J.Pharmacol. 195 333 PMID: 1868879

Eltze et al (1985) Pharmacological evidence for selective inhibition of gastric acid secretion by telenzepine, a new antimuscarinic drug. Eur.J.Pharmacol. 112 211 PMID: 4029260

Galvan et al (1989) Interaction of telenzepine with muscarinic receptors in mammalian sympathetic ganglia. Eur.J.Pharmacol. 167 1 PMID: 2776837

If you know of a relevant reference for Telenzepine dihydrochloride, please let us know.

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关键词: Telenzepine dihydrochloride, Telenzepine dihydrochloride supplier, Potent, selective, M1, antagonists, Muscarinic, Receptors, Acetylcholine, ACh, 1122, Tocris Bioscience

1 篇 Telenzepine dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Telenzepine dihydrochloride 的部分引用包括：

Pediani et al (2016) Dynamic regulation of quaternary organization of the M₁ muscarinic receptor by subtype-selective antagonist drugs. J.Biol.Chem. 291 13132 PMID: 27080256

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