Teniposide

Cat. No. 6975 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： DNA topoisomerase II inhibitor; viral transduction enhancer

化学名： (5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Teniposide

Teniposide is a DNA topoisomerase II inhibitor and viral transduction enhancer. It induces breaks in double-stranded DNA and prevents DNA repair. Teniposide enhances transduction of recombinant adeno-associated virus 2 (rAAV2) by up to 40-fold in human cells in vitro and by 100-fold in vivo at 24 h post-transduction.

技术数据 for Teniposide

分子量	656.66
公式	C₃₂H₃₂O₁₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	29767-20-2
PubChem ID	452548
InChI Key	NRUKOCRGYNPUPR-QBPJDGROSA-N
Smiles	[H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@]1([H])O[C@]2([H])CO[C@H](O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Teniposide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	65.67	100

制备储备液 for Teniposide

以下数据基于产品分子量 656.66。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.52 mL	7.61 mL	15.23 mL
5 mM	0.3 mL	1.52 mL	3.05 mL
10 mM	0.15 mL	0.76 mL	1.52 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

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产品说明书 for Teniposide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Teniposide

参考文献是支持产品生物活性的出版物。

Nicolson et al (2016) Identification and validation of small molecules that enhance recombinant adeno-associated virus transduction following high-throughput screens. J.Virol. 90 7019 PMID: 27147738

Yusenko et al (2018) A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity. Sci.Rep. 8 13159 PMID: 30177851

If you know of a relevant reference for Teniposide, please let us know.

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关键词: Teniposide, Teniposide supplier, DNA, topoisomerase, II, inhibitors, viral, transduction, enhancers, adeno-associated, virus, 2, Viral, Transduction, Enhancers, Topoisomerase, 6975, Tocris Bioscience

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